TY - JOUR
T1 - Selective Peroxygenase-Catalysed Oxidation of Toluene Derivates to Benzaldehydes
AU - Wang, Yutong
AU - Teetz, Niklas
AU - Holtmann, Dirk
AU - Alcalde, Miguel
AU - van Hengst, Jacob M.A.
AU - Liu, Xiaoxiao
AU - Wang, Mengfan
AU - Qi, Wei
AU - Zhang, Wuyuan
AU - Hollmann, Frank
PY - 2023
Y1 - 2023
N2 - Biocatalytic oxidation reactions of toluene derivates to the corresponding aldehydes are typically challenged by regio- and chemoselectivity issues. In this contribution we address both challenges by a combined reactant- and reaction engineering approach. We demonstrate that the peroxygenase-catalysed transformation of ring-substituted toluenes proceeds highly regioselectively in benzylic position. Furthermore, neat reaction conditions not only enable attractive product concentrations (up to 185 mM) but also result in highly chemoselective oxidations to the aldehyde level.
AB - Biocatalytic oxidation reactions of toluene derivates to the corresponding aldehydes are typically challenged by regio- and chemoselectivity issues. In this contribution we address both challenges by a combined reactant- and reaction engineering approach. We demonstrate that the peroxygenase-catalysed transformation of ring-substituted toluenes proceeds highly regioselectively in benzylic position. Furthermore, neat reaction conditions not only enable attractive product concentrations (up to 185 mM) but also result in highly chemoselective oxidations to the aldehyde level.
KW - Benzaldehydes
KW - Biocatalytic oxidation
KW - Peroxygenase
KW - Selective oxyfunctionalisation
KW - Solvent-free biocatalysis
UR - http://www.scopus.com/inward/record.url?scp=85162015029&partnerID=8YFLogxK
U2 - 10.1002/cctc.202300645
DO - 10.1002/cctc.202300645
M3 - Article
AN - SCOPUS:85162015029
SN - 1867-3880
VL - 15
JO - ChemCatChem
JF - ChemCatChem
IS - 13
M1 - e202300645
ER -