Sensitivity of a two-dimensional biomorphoelastic model for post-burn contraction

Ginger Egberts*, Alexis Desmoulière, Fred Vermolen, Paul van Zuijlen

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

2 Citations (Scopus)
37 Downloads (Pure)

Abstract

We consider a two-dimensional biomorphoelastic model describing post-burn scar contraction. This model describes skin displacement and the development of the effective Eulerian strain in the tissue. Besides these mechanical components, signaling molecules, fibroblasts, myofibroblasts, and collagen also play a significant role in the model. We perform a sensitivity analysis for the independent parameters of the model and focus on the effects on features of the relative surface area and the total strain energy density. We conclude that the most sensitive parameters are the Poisson’s ratio, the equilibrium collagen concentration, the contraction inhibitor constant, and the myofibroblast apoptosis rate. Next to these insights, we perform a sensitivity analysis where the proliferation rates of fibroblasts and myofibroblasts are not the same. The impact of this model adaptation is significant.

Original languageEnglish
Pages (from-to)105-121
Number of pages17
JournalBiomechanics and Modeling in Mechanobiology
Volume22
Issue number1
DOIs
Publication statusPublished - 2022

Keywords

  • Burn
  • Cell proliferation
  • Morphoelasticity
  • Moving-grid finite-element
  • Sensitivity
  • Wound contraction

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