Research output per year
Research output per year
Ginger Egberts*, Alexis Desmoulière, Fred Vermolen, Paul van Zuijlen
Research output: Contribution to journal › Article › Scientific › peer-review
We consider a two-dimensional biomorphoelastic model describing post-burn scar contraction. This model describes skin displacement and the development of the effective Eulerian strain in the tissue. Besides these mechanical components, signaling molecules, fibroblasts, myofibroblasts, and collagen also play a significant role in the model. We perform a sensitivity analysis for the independent parameters of the model and focus on the effects on features of the relative surface area and the total strain energy density. We conclude that the most sensitive parameters are the Poisson’s ratio, the equilibrium collagen concentration, the contraction inhibitor constant, and the myofibroblast apoptosis rate. Next to these insights, we perform a sensitivity analysis where the proliferation rates of fibroblasts and myofibroblasts are not the same. The impact of this model adaptation is significant.
Original language | English |
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Pages (from-to) | 105-121 |
Number of pages | 17 |
Journal | Biomechanics and Modeling in Mechanobiology |
Volume | 22 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2022 |
Research output: Thesis › Dissertation (TU Delft)
Egberts, G. (Creator), Vermolen, F. J. (Creator), van Zuijlen, P. (Creator) & Desmoulière, A. (Creator), TU Delft - 4TU.ResearchData, 27 Oct 2022
DOI: 10.4121/21400608
Dataset/Software: Dataset
Egberts, G. (Creator), Vermolen, F. J. (Creator), van Zuijlen, P. (Creator) & Desmoulière, A. (Creator), TU Delft - 4TU.ResearchData, 27 Oct 2022
DOI: 10.4121/21400281
Dataset/Software: Software