Simple Accurate Verification of Enthalpy-Entropy Compensation and Isoequilibrium Relationship

Ronald Griessen*, Bernard Dam

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)
37 Downloads (Pure)

Abstract

In many experimental investigations of thermodynamic equilibrium or kinetic properties of series of similar reactions it is found that the enthalpies and entropies derived from Van ′t Hoff or Arrhenius plots exhibit a strong linear correlation. The origin of this Enthalpy-Entropy compensation, which is strongly related to the coalescence tendency of Van ′t Hoff or Arrhenius plots, is not necessarily due to a physical/chemical/biological process. It can also be a merely statistical artefact. A new method, called Combined K-CQF makes it possible both to quantify the degree of coalescence of experimental Van ‘t Hoff lines and to verify whether or not the Enthalpy-Entropy Compensation is of a statistical origin at a desired confidence level. The method is universal and can handle data sets with any degree of coalescence of Van ‘t Hoff (or Arrhenius) plots. The new method requires only a standard least square fit of the enthalpyΔH versus entropy ΔS plot to determine the two essential dimensionless parameters K and CQF. The parameter K indicates the position (in inverse temperature) of the coalescence region of Van ‘t Hoff plots and CQF is a quantitative measure of the smallest spread of the Van ‘t Hoff plots. The position of the (K, CQF) couple with respect to universal confidence contours determined from a large number of simulations of random Van ‘t Hoff plots indicates straightforwardly whether or not the ΔH-ΔS compensation is a statistical artefact.

Original languageEnglish
Pages (from-to)1774-1784
Number of pages11
JournalChemPhysChem
Volume22
Issue number17
DOIs
Publication statusPublished - 2021

Keywords

  • artifacts
  • isokinetic temperature
  • simulations
  • statistics
  • thermodynamics

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