Single-cell immune profiling reveals thymus-seeding populations, T cell commitment, and multilineage development in the human thymus

Martijn Cordes, Kirsten Canté-Barrett, Erik B. van den Akker, Federico A. Moretti, Szymon M. Kiełbasa, Sandra A. Vloemans, Laura Garcia-Perez, Cristina Teodosio, Jacques J.M. van Dongen, Karin Pike-Overzet, Marcel J.T. Reinders, Frank J.T. Staal

Research output: Contribution to journalArticleScientificpeer-review

19 Downloads (Pure)

Abstract

T cell development in the mouse thymus has been studied extensively, but less is known regarding T cell development in the human thymus. We used a combination of single-cell techniques and functional assays to perform deep immune profiling of human T cell development, focusing on the initial stages of prelineage commitment. We identified three thymus-seeding progenitor populations that also have counterparts in the bone marrow. In addition, we found that the human thymus physiologically supports the development of monocytes, dendritic cells, and NK cells, as well as limited development of B cells. These results are an important step toward monitoring and guiding regenerative therapies in patients after hematopoietic stem cell transplantation.

Original languageEnglish
Pages (from-to)eade0182
JournalScience immunology
Volume7
Issue number77
DOIs
Publication statusPublished - 2022

Bibliographical note

Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care
Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

Fingerprint

Dive into the research topics of 'Single-cell immune profiling reveals thymus-seeding populations, T cell commitment, and multilineage development in the human thymus'. Together they form a unique fingerprint.

Cite this