TY - JOUR
T1 - Single-cell immune profiling reveals thymus-seeding populations, T cell commitment, and multilineage development in the human thymus
AU - Cordes, Martijn
AU - Canté-Barrett, Kirsten
AU - van den Akker, Erik B.
AU - Moretti, Federico A.
AU - Kiełbasa, Szymon M.
AU - Vloemans, Sandra A.
AU - Garcia-Perez, Laura
AU - Teodosio, Cristina
AU - van Dongen, Jacques J.M.
AU - Pike-Overzet, Karin
AU - Reinders, Marcel J.T.
AU - Staal, Frank J.T.
N1 - Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care
Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.
PY - 2022
Y1 - 2022
N2 - T cell development in the mouse thymus has been studied extensively, but less is known regarding T cell development in the human thymus. We used a combination of single-cell techniques and functional assays to perform deep immune profiling of human T cell development, focusing on the initial stages of prelineage commitment. We identified three thymus-seeding progenitor populations that also have counterparts in the bone marrow. In addition, we found that the human thymus physiologically supports the development of monocytes, dendritic cells, and NK cells, as well as limited development of B cells. These results are an important step toward monitoring and guiding regenerative therapies in patients after hematopoietic stem cell transplantation.
AB - T cell development in the mouse thymus has been studied extensively, but less is known regarding T cell development in the human thymus. We used a combination of single-cell techniques and functional assays to perform deep immune profiling of human T cell development, focusing on the initial stages of prelineage commitment. We identified three thymus-seeding progenitor populations that also have counterparts in the bone marrow. In addition, we found that the human thymus physiologically supports the development of monocytes, dendritic cells, and NK cells, as well as limited development of B cells. These results are an important step toward monitoring and guiding regenerative therapies in patients after hematopoietic stem cell transplantation.
UR - http://www.scopus.com/inward/record.url?scp=85141683601&partnerID=8YFLogxK
U2 - 10.1126/sciimmunol.ade0182
DO - 10.1126/sciimmunol.ade0182
M3 - Article
C2 - 36367948
AN - SCOPUS:85141683601
SN - 2470-9468
VL - 7
SP - eade0182
JO - Science immunology
JF - Science immunology
IS - 77
ER -