Single Microbubble Measurements for Bound and Unbound Conditions

Jordan S. Lum, Verya Daeichin, Todd W. Murray, Mark A. Borden

    Research output: Chapter in Book/Conference proceedings/Edited volumeConference contributionScientificpeer-review


    We show here that adhesion to a solid substrate increases the resonance frequency of a lipid-coated microbubble by causing an apparent increase in shell stiffness. Using our previously developed photoacoustic measurement technique to drive individual microbubbles into small-amplitude oscillations, we found that biotinylated microbubbles adherent to a streptavidin-coated glass coverslip had much higher resonance frequencies than unbound microbubbles. The frequency responses of the bound microbubbles agree well with a linearized form of the modified Rayleigh-Plesset model with an added increase of shell elasticity. The apparent shell elasticity increased from 0.5 N/m for unbound microbubbles to 2.6 N/m. These findings may be used to better understand microbubble dynamics for applications in ultrasound imaging and therapy.

    Original languageEnglish
    Title of host publication2019 IEEE International Ultrasonics Symposium, IUS 2019
    EditorsSandy Cochran, Margaret Lucas
    ISBN (Electronic)9781728145969
    Publication statusPublished - 2019
    Event2019 IEEE International Ultrasonics Symposium, IUS 2019 - Glasgow, United Kingdom
    Duration: 6 Oct 20199 Oct 2019


    Conference2019 IEEE International Ultrasonics Symposium, IUS 2019
    CountryUnited Kingdom


    • adhesion
    • resonance frequency
    • shell elasticity


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