Single Microbubble Measurements for Bound and Unbound Conditions

Jordan S. Lum; Verya Daeichin; Todd W. Murray; Mark A. Borden

doi:10.1109/ULTSYM.2019.8925943

Single Microbubble Measurements for Bound and Unbound Conditions

Jordan S. Lum, Verya Daeichin, Todd W. Murray, Mark A. Borden

Research output: Chapter in Book/Conference proceedings/Edited volume › Conference contribution › Scientific › peer-review

Abstract

We show here that adhesion to a solid substrate increases the resonance frequency of a lipid-coated microbubble by causing an apparent increase in shell stiffness. Using our previously developed photoacoustic measurement technique to drive individual microbubbles into small-amplitude oscillations, we found that biotinylated microbubbles adherent to a streptavidin-coated glass coverslip had much higher resonance frequencies than unbound microbubbles. The frequency responses of the bound microbubbles agree well with a linearized form of the modified Rayleigh-Plesset model with an added increase of shell elasticity. The apparent shell elasticity increased from 0.5 N/m for unbound microbubbles to 2.6 N/m. These findings may be used to better understand microbubble dynamics for applications in ultrasound imaging and therapy.

Original language	English
Title of host publication	2019 IEEE International Ultrasonics Symposium, IUS 2019
Editors	Sandy Cochran, Margaret Lucas
Publisher	IEEE
Pages	822-824
Volume	2019-October
ISBN (Electronic)	9781728145969
DOIs	https://doi.org/10.1109/ULTSYM.2019.8925943
Publication status	Published - 2019
Event	2019 IEEE International Ultrasonics Symposium, IUS 2019 - Glasgow, United Kingdom Duration: 6 Oct 2019 → 9 Oct 2019

Conference

Conference	2019 IEEE International Ultrasonics Symposium, IUS 2019
Country/Territory	United Kingdom
City	Glasgow
Period	6/10/19 → 9/10/19

Keywords

adhesion
resonance frequency
shell elasticity

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10.1109/ULTSYM.2019.8925943

Cite this

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title = "Single Microbubble Measurements for Bound and Unbound Conditions",

abstract = "We show here that adhesion to a solid substrate increases the resonance frequency of a lipid-coated microbubble by causing an apparent increase in shell stiffness. Using our previously developed photoacoustic measurement technique to drive individual microbubbles into small-amplitude oscillations, we found that biotinylated microbubbles adherent to a streptavidin-coated glass coverslip had much higher resonance frequencies than unbound microbubbles. The frequency responses of the bound microbubbles agree well with a linearized form of the modified Rayleigh-Plesset model with an added increase of shell elasticity. The apparent shell elasticity increased from 0.5 N/m for unbound microbubbles to 2.6 N/m. These findings may be used to better understand microbubble dynamics for applications in ultrasound imaging and therapy.",

keywords = "adhesion, resonance frequency, shell elasticity",

author = "Lum, {Jordan S.} and Verya Daeichin and Murray, {Todd W.} and Borden, {Mark A.}",

year = "2019",

doi = "10.1109/ULTSYM.2019.8925943",

language = "English",

volume = "2019-October",

pages = "822--824",

editor = "Cochran, {Sandy } and {Lucas }, {Margaret }",

booktitle = "2019 IEEE International Ultrasonics Symposium, IUS 2019",

publisher = "IEEE",

address = "United States",

note = "2019 IEEE International Ultrasonics Symposium, IUS 2019 ; Conference date: 06-10-2019 Through 09-10-2019",

}

Lum, JS, Daeichin, V, Murray, TW & Borden, MA 2019, Single Microbubble Measurements for Bound and Unbound Conditions. in S Cochran & M Lucas (eds), 2019 IEEE International Ultrasonics Symposium, IUS 2019. vol. 2019-October, 8925943, IEEE, pp. 822-824, 2019 IEEE International Ultrasonics Symposium, IUS 2019, Glasgow, United Kingdom, 6/10/19. https://doi.org/10.1109/ULTSYM.2019.8925943

Single Microbubble Measurements for Bound and Unbound Conditions. / Lum, Jordan S.; Daeichin, Verya; Murray, Todd W. et al.
2019 IEEE International Ultrasonics Symposium, IUS 2019. ed. / Sandy Cochran; Margaret Lucas . Vol. 2019-October IEEE, 2019. p. 822-824 8925943.

Research output: Chapter in Book/Conference proceedings/Edited volume › Conference contribution › Scientific › peer-review

TY - GEN

T1 - Single Microbubble Measurements for Bound and Unbound Conditions

AU - Lum, Jordan S.

AU - Daeichin, Verya

AU - Murray, Todd W.

AU - Borden, Mark A.

PY - 2019

Y1 - 2019

N2 - We show here that adhesion to a solid substrate increases the resonance frequency of a lipid-coated microbubble by causing an apparent increase in shell stiffness. Using our previously developed photoacoustic measurement technique to drive individual microbubbles into small-amplitude oscillations, we found that biotinylated microbubbles adherent to a streptavidin-coated glass coverslip had much higher resonance frequencies than unbound microbubbles. The frequency responses of the bound microbubbles agree well with a linearized form of the modified Rayleigh-Plesset model with an added increase of shell elasticity. The apparent shell elasticity increased from 0.5 N/m for unbound microbubbles to 2.6 N/m. These findings may be used to better understand microbubble dynamics for applications in ultrasound imaging and therapy.

AB - We show here that adhesion to a solid substrate increases the resonance frequency of a lipid-coated microbubble by causing an apparent increase in shell stiffness. Using our previously developed photoacoustic measurement technique to drive individual microbubbles into small-amplitude oscillations, we found that biotinylated microbubbles adherent to a streptavidin-coated glass coverslip had much higher resonance frequencies than unbound microbubbles. The frequency responses of the bound microbubbles agree well with a linearized form of the modified Rayleigh-Plesset model with an added increase of shell elasticity. The apparent shell elasticity increased from 0.5 N/m for unbound microbubbles to 2.6 N/m. These findings may be used to better understand microbubble dynamics for applications in ultrasound imaging and therapy.

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KW - resonance frequency

KW - shell elasticity

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DO - 10.1109/ULTSYM.2019.8925943

M3 - Conference contribution

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VL - 2019-October

SP - 822

EP - 824

BT - 2019 IEEE International Ultrasonics Symposium, IUS 2019

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PB - IEEE

T2 - 2019 IEEE International Ultrasonics Symposium, IUS 2019

Y2 - 6 October 2019 through 9 October 2019

ER -

Single Microbubble Measurements for Bound and Unbound Conditions

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Keywords

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