Spectroscopic photoacoustic imaging of radiofrequency ablation in the left atrium

Sophinese Iskander-Rizk, Pieter Kruizinga, Antonius F.W. Van Der Steen, Gijs Van Soest, Ton van der Steen

    Research output: Contribution to journalArticleScientificpeer-review

    20 Citations (Scopus)
    15 Downloads (Pure)

    Abstract

    Catheter-based radiofrequency ablation for atrial fibrillation has long-term success in 60-70% of cases. A better assessment of lesion quality, depth, and continuity could improve the procedure’s outcome. We investigate here photoacoustic contrast between ablated and healthy atrial-wall tissue in vitro in wavelengths spanning from 410 nm to 1000 nm. We studied single-and multi-wavelength imaging of ablation lesions and we demonstrate that a two-wavelength technique yields precise detection of lesions, achieving a diagnostic accuracy of 97%. We compare this with a best single-wavelength (640 nm) analysis that correctly identifies 82% of lesions. We discuss the origin of relevant spectroscopic features and perspectives for translation to clinical imaging.

    Original languageEnglish
    Article number#309967
    JournalBiomedical Optics Express
    Volume9
    Issue number3
    DOIs
    Publication statusPublished - 2018

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