TY - JOUR

T1 - Spin-echo small-angle neutron scattering study of the structure organization of the chromatin in biological cell

AU - Iashina, E.G.

AU - Bouwman, W. G.

AU - Duif, C. P.

AU - Filatov, M.V.

AU - Grigoriev, S. V.

PY - 2017/6/20

Y1 - 2017/6/20

N2 - Spin-echo small-angle scattering (SESANS) technique is a method to measure the structure of materials from nano- to micrmeter length scales. This method could be important for studying the packaging of DNA in the eukaryotic cell. We measured the SESANS function from chicken erythrocyte nuclei which is well fitted by the exponential function G(z) = exp(-z/ξ), where ξ is the correlation length of a nucleus (in experimental data ξ = 3, 3 μm). The exponential decay of G(z) corresponds to the logarithmic pair correlation function γ(r) = ln(ξ/r). As the sensitivity of the SESANS signal depends on the neutron wavelength, we propose the SESANS setup with the changeable wavelength in the range from 2 to 12 Å. Such option allows one to study in great detail the internal structure of the biological cell in the length scale from 10-2 μm to 10 μm.

AB - Spin-echo small-angle scattering (SESANS) technique is a method to measure the structure of materials from nano- to micrmeter length scales. This method could be important for studying the packaging of DNA in the eukaryotic cell. We measured the SESANS function from chicken erythrocyte nuclei which is well fitted by the exponential function G(z) = exp(-z/ξ), where ξ is the correlation length of a nucleus (in experimental data ξ = 3, 3 μm). The exponential decay of G(z) corresponds to the logarithmic pair correlation function γ(r) = ln(ξ/r). As the sensitivity of the SESANS signal depends on the neutron wavelength, we propose the SESANS setup with the changeable wavelength in the range from 2 to 12 Å. Such option allows one to study in great detail the internal structure of the biological cell in the length scale from 10-2 μm to 10 μm.

UR - http://resolver.tudelft.nl/uuid:a376fd3d-021b-4654-aa44-c650634e7683

UR - http://www.scopus.com/inward/record.url?scp=85040723666&partnerID=8YFLogxK

U2 - 10.1088/1742-6596/862/1/012010

DO - 10.1088/1742-6596/862/1/012010

M3 - Conference article

AN - SCOPUS:85040723666

SN - 1742-6588

VL - 862

JO - Journal of Physics: Conference Series

JF - Journal of Physics: Conference Series

IS - 1

M1 - 012010

ER -