Stability analysis of an artificial biomolecular oscillator with non-cooperative regulatory interactions

Christian Cuba Samaniego, Giulia Giordano, Franco Blanchini, Elisa Franco

Research output: Contribution to journalArticleScientificpeer-review

9 Citations (Scopus)

Abstract

Oscillators are essential to fuel autonomous behaviours in molecular systems. Artificial oscillators built with programmable biological molecules such as DNA and RNA are generally easy to build and tune, and can serve as timers for biological computation and regulation. We describe a new artificial nucleic acid biochemical reaction network, andwedemonstrate its capacity to exhibit oscillatory solutions. This network can be built in vitro using nucleic acids and three bacteriophage enzymes, and has the potential to be implemented in cells. Numerical simulations suggest that oscillations occur in a realistic range of reaction rates and concentrations.

Original languageEnglish
Pages (from-to)102-120
Number of pages19
JournalJournal of Biological Dynamics
Volume11
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017
Externally publishedYes

Keywords

  • Biochemistry
  • Biological applications
  • Molecular biology
  • Nonlinear oscillations
  • Nonlinear systems

Fingerprint Dive into the research topics of 'Stability analysis of an artificial biomolecular oscillator with non-cooperative regulatory interactions'. Together they form a unique fingerprint.

Cite this