Stent with Piezoelectric Transducers for High Spatial Resolution Ultrasound Neuromodulation- a Finite Element Analysis

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Abstract

Deep brain stimulation is currently the only technique used in the clinical setting to modulate the neural activity of deep brain nuclei. Recently, low-intensity transcranial focused ultrasound (LIFU) has been shown to reversibly modulate brain activity through a transcranial pathway. Transcranial LIFU requires a low-frequency ultrasound of around 0.5 MHz due to skull attenuation, thus providing poor axial and lateral resolution. This paper proposes a new conceptual device that would use a stent to place a high-frequency ultrasound array within the brain vasculature to achieve high axial and lateral spatial resolution. The first part of this work identified the most commonly treated deep brain nuclei and examined the human brain vasculature for stent placement. Next, a finite element analysis was carried out using a piezoelectric array that follows the blood vessels curvature, and its ability to focus ultrasound waves in clinically relevant brain nuclei was evaluated. The analytical solution provided promising results for deep brain stimulation via a stent with ultrasound transducers for high spatial resolution neuromodulation.
Original languageEnglish
Title of host publicationProceedings of the 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
PublisherIEEE
Pages4966-4969
Number of pages4
ISBN (Electronic)978-1-7281-2782-8
ISBN (Print)978-1-7281-2783-5
DOIs
Publication statusPublished - 2022
Event2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) - Glasgow, United Kingdom
Duration: 11 Jul 202215 Jul 2022
Conference number: 44th

Conference

Conference2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
Country/TerritoryUnited Kingdom
CityGlasgow
Period11/07/2215/07/22

Bibliographical note

Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care
Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

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