Structural stability of biochemical networks: Quadratic vs. polyhedral Lyapunov functions

Due to the intrinsic uncertainty and variability affecting biochemical reaction networks, it is fundamental to assess their structural stability, i.e., to establish if all the networks having a given structure are stable independent of specific parameter values. For basic motifs in biochemical networks, we show that stability cannot be structurally proved by quadratic Lyapunov functions. However, structural stability of these motifs can be shown resorting to piecewise-linear Lyapunov functions, based on the results by Blanchini and Giordano (2014), who provide a theoretical framework and efficient numerical methods to evaluate structural stability of biochemical reaction networks with monotone reaction rates.