Synthesis and evaluation of porous titanium scaffolds prepared with the space holder method for bone tissue engineering

Budi Arifvianto

Research output: ThesisDissertation (TU Delft)

48 Downloads (Pure)


Loss of function and impaired life quality as a result of large bone defects remain a serious problem in the society. Basically, the bone tissue has the capability of healing by itself when fractured. However, impaired healing may occur, leading to delayed union or even non-union when a bone segment is excised above a critical size. In recent years, bone tissue engineering has received increasing attention in the biomedical research community as an alternative approach to bone defect reconstruction. With this approach, damaged bone tissue can be repaired and remodelled with new bone cells at the defect site. For this purpose, a synthetic porous material, namely scaffold, is needed to act as a template to facilitate cellular activities, such as the migration
and proliferation of osteoblasts and mesenchymal cells, as well as the transport of nutrients and oxygen required for vascularization during bone tissue development at the defect site. Currently, titanium is considered to be a preferred biomaterial for bone tissue engineering scaffolds owing to its excellent biocompatibility and mechanical properties. So far, the space holder method has been preferably used for the fabrication of titanium scaffolds with high porosity and open, interconnected pores for bone tissue engineering. Despite a large number of studies on the scaffold fabrication with this method, the mechanisms involved and the way to control the porous structure of scaffolds during fabrication have not yet been fully understood.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Delft University of Technology
  • van der Helm, F.C.T., Supervisor
  • Zhou, J., Advisor
Award date25 Oct 2017
Print ISBNs978-94-6186-851-0
Publication statusPublished - 2017


  • synthesis
  • evaluation
  • titanium scaffold
  • space holder method
  • bone tissue engineering


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