“Aging” is the accumulation process of diverse detrimental changes in molecular structures with advancing age. Resistance to aging is termed “durability.” Complex molecular systems such as asphalt binder (AB) need to be protected against aging. This paper provides a state-of-the-art review of antiaging technologies used to prohibit or to rejuvenate aged asphaltic materials. The kinetics of molecular structures during aging and the group of molecules that mainly are affected are discussed. The latest developments in antioxidation and rejuvenation technologies are presented, as well as evidence of the impact of antiaging technologies on AB.