Synthesis of enantiomerically pure alcohols and amines: Via biocatalytic deracemisation methods

Musa M. Musa*, Frank Hollmann, Francesco G. Mutti

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)
56 Downloads (Pure)

Abstract

Deracemisation via chemo-enzymatic or multi-enzymatic approaches is the optimum substitute for kinetic resolution, which suffers from the limitation of a theoretical maximum 50% yield albeit high enantiomeric excess is attainable. This review covers the recent progress in various deracemisation approaches applied to the synthesis of enantiomerically pure alcohols and amines, such as (1) dynamic kinetic resolution, (2) cyclic deracemisation, (3) linear deracemisation (including stereoinversion) and (4) enantioconvergent methods.

Original languageEnglish
Pages (from-to)5487-5503
JournalCatalysis Science and Technology
Volume9
Issue number20
DOIs
Publication statusPublished - 2019

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