TY - JOUR
T1 - Synthesis of Enantiopure Vicinal Halohydrins Using a Sequence of Haloperoxidase and Lipase
AU - De Marchi, Elisa
AU - Hilberath, Thomas
AU - Zippilli, Claudio
AU - Wever, Ron
AU - Saladino, Raffaele
AU - Hollmann, Frank
AU - Botta, Lorenzo
PY - 2024
Y1 - 2024
N2 - Vicinal halohydrins are key building blocks to produce bioactive molecules and drugs, especially if they can be obtained in enantiomerically pure form. In this study, we present a bi-enzymatic sequence that allows to obtain vic-halohydrins through a photochemoenzymatic olefin hydroxy halogenation followed by a lipase catalysed kinetic resolution. The absolute configuration of the resulting products was determined using Mosher's method.
AB - Vicinal halohydrins are key building blocks to produce bioactive molecules and drugs, especially if they can be obtained in enantiomerically pure form. In this study, we present a bi-enzymatic sequence that allows to obtain vic-halohydrins through a photochemoenzymatic olefin hydroxy halogenation followed by a lipase catalysed kinetic resolution. The absolute configuration of the resulting products was determined using Mosher's method.
KW - Candida antarctica lipase B
KW - cascade reaction
KW - enzymatic kinetic resolution
KW - photochemoenzymatic cascade
KW - vanadium chloroperoxidase
UR - http://www.scopus.com/inward/record.url?scp=85199266440&partnerID=8YFLogxK
U2 - 10.1002/adsc.202400516
DO - 10.1002/adsc.202400516
M3 - Article
AN - SCOPUS:85199266440
SN - 1615-4150
VL - 366
SP - 3290
EP - 3296
JO - Advanced Synthesis and Catalysis
JF - Advanced Synthesis and Catalysis
IS - 15
ER -