Targeted brain activation using an MR-compatible wrist torque measurement device and isometric motor tasks during functional magnetic resonance imaging

Martijn P. Vlaar, Winfred Mugge, Paul F C Groot, Sarvi Sharifi, Lo J. Bour, Frans C T van der Helm, Anne Fleur van Rootselaar, Alfred C. Schouten

Research output: Contribution to journalArticleScientificpeer-review

4 Citations (Scopus)

Abstract

Dedicated pairs of isometric wrist flexion tasks, with and without visual feedback of the exerted torque, were designed to target activation of the CBL and BG in healthy subjects during functional magnetic resonance imaging (fMRI). Selective activation of the cerebellum (CBL) and basal ganglia (BG), often implicated in movement disorders such as tremor and dystonia, may help identify pathological changes and expedite diagnosis. A prototyped MR-compatible wrist torque measurement device, free of magnetic and conductive materials, allowed safe execution of tasks during fMRI without causing artifacts. A significant increase of activity in CBL and BG was found in healthy volunteers during a constant torque task with visual feedback compared to a constant torque task without visual feedback. This study shows that specific pairs of motor tasks using MR-compatible equipment at the wrist allow for targeted activation of CBL and BG, paving a new way for research into the pathophysiology of movement disorders.

Original languageEnglish
Pages (from-to)795-802
JournalMagnetic Resonance Imaging
Volume34
Issue number6
DOIs
Publication statusPublished - 2016

Keywords

  • Basal ganglia
  • Cerebellum
  • FMRI
  • Functional magnetic resonance imaging
  • Isometric motor tasks
  • Optical force sensor

Fingerprint Dive into the research topics of 'Targeted brain activation using an MR-compatible wrist torque measurement device and isometric motor tasks during functional magnetic resonance imaging'. Together they form a unique fingerprint.

  • Cite this