TY - JOUR
T1 - Targeted brain activation using an MR-compatible wrist torque measurement device and isometric motor tasks during functional magnetic resonance imaging
AU - Vlaar, Martijn P.
AU - Mugge, Winfred
AU - Groot, Paul F C
AU - Sharifi, Sarvi
AU - Bour, Lo J.
AU - van der Helm, Frans C T
AU - van Rootselaar, Anne Fleur
AU - Schouten, Alfred C.
PY - 2016
Y1 - 2016
N2 - Dedicated pairs of isometric wrist flexion tasks, with and without visual feedback of the exerted torque, were designed to target activation of the CBL and BG in healthy subjects during functional magnetic resonance imaging (fMRI). Selective activation of the cerebellum (CBL) and basal ganglia (BG), often implicated in movement disorders such as tremor and dystonia, may help identify pathological changes and expedite diagnosis. A prototyped MR-compatible wrist torque measurement device, free of magnetic and conductive materials, allowed safe execution of tasks during fMRI without causing artifacts. A significant increase of activity in CBL and BG was found in healthy volunteers during a constant torque task with visual feedback compared to a constant torque task without visual feedback. This study shows that specific pairs of motor tasks using MR-compatible equipment at the wrist allow for targeted activation of CBL and BG, paving a new way for research into the pathophysiology of movement disorders.
AB - Dedicated pairs of isometric wrist flexion tasks, with and without visual feedback of the exerted torque, were designed to target activation of the CBL and BG in healthy subjects during functional magnetic resonance imaging (fMRI). Selective activation of the cerebellum (CBL) and basal ganglia (BG), often implicated in movement disorders such as tremor and dystonia, may help identify pathological changes and expedite diagnosis. A prototyped MR-compatible wrist torque measurement device, free of magnetic and conductive materials, allowed safe execution of tasks during fMRI without causing artifacts. A significant increase of activity in CBL and BG was found in healthy volunteers during a constant torque task with visual feedback compared to a constant torque task without visual feedback. This study shows that specific pairs of motor tasks using MR-compatible equipment at the wrist allow for targeted activation of CBL and BG, paving a new way for research into the pathophysiology of movement disorders.
KW - Basal ganglia
KW - Cerebellum
KW - FMRI
KW - Functional magnetic resonance imaging
KW - Isometric motor tasks
KW - Optical force sensor
UR - http://www.scopus.com/inward/record.url?scp=84962909737&partnerID=8YFLogxK
U2 - 10.1016/j.mri.2016.02.002
DO - 10.1016/j.mri.2016.02.002
M3 - Article
AN - SCOPUS:84962909737
SN - 0730-725X
VL - 34
SP - 795
EP - 802
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
IS - 6
ER -