The Advent of Biomolecular Ultrasound Imaging

Baptiste Heiles, Dion Terwiel, David Maresca*

*Corresponding author for this work

Research output: Contribution to journalReview articleScientificpeer-review

1 Citation (Scopus)
5 Downloads (Pure)


Ultrasound imaging is one of the most widely used modalities in clinical practice, revealing human prenatal development but also arterial function in the adult brain. Ultrasound waves travel deep within soft biological tissues and provide information about the motion and mechanical properties of internal organs. A drawback of ultrasound imaging is its limited ability to detect molecular targets due to a lack of cell-type specific acoustic contrast. To date, this limitation has been addressed by targeting synthetic ultrasound contrast agents to molecular targets. This molecular ultrasound imaging approach has proved to be successful but is restricted to the vascular space. Here, we introduce the nascent field of biomolecular ultrasound imaging, a molecular imaging approach that relies on genetically encoded acoustic biomolecules to interface ultrasound waves with cellular processes. We review ultrasound imaging applications bridging wave physics and chemical engineering with potential for deep brain imaging.

Original languageEnglish
Pages (from-to)122-133
Publication statusPublished - 2021


  • acoustic biosensors
  • biomolecular ultrasound
  • functional ultrasound imaging
  • gas vesicles
  • neuroimaging
  • ultrasound contrast agents


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