The clinical utilities of multi-pinhole single photon emission computed tomography

Ilker Ozsahin, Ling Chen, Arda Könik, Michael A. King, Freek J. Beekman, Greta S.P. Mok*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)
78 Downloads (Pure)


Single photon emission computed tomography (SPECT) is an important imaging modality for various applications in nuclear medicine. The use of multi-pinhole (MPH) collimators can provide superior resolution-sensitivity trade-off when imaging small field-of-view compared to conventional parallel-hole and fan-beam collimators. Besides the very successful application in small animal imaging, there has been a resurgence of the use of MPH collimators for clinical cardiac and brain studies, as well as other small field-of-view applications. This article reviews the basic principles of MPH collimators and introduces currently available and proposed clinical MPH SPECT systems.

Original languageEnglish
Pages (from-to)2006-2029
JournalQuantitative Imaging in Medicine and Surgery
Issue number10
Publication statusPublished - 2020


  • Brain
  • Cardiac
  • Collimator
  • Multi-pinhole
  • Single photon emission computed tomography (SPECT)

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