TY - JOUR
T1 - The extracellular matrix as hallmark of cancer and metastasis
T2 - From biomechanics to therapeutic targets
AU - Sleeboom, Jelle J.F.
AU - van Tienderen, Gilles S.
AU - Schenke-Layland, Katja
AU - van der Laan, Luc J.W.
AU - Khalil, Antoine A.
AU - Verstegen, Monique M.A.
PY - 2024
Y1 - 2024
N2 - The extracellular matrix (ECM) is essential for cell support during homeostasis and plays a critical role in cancer. Although research often concentrates on the tumor's cellular aspect, attention is growing for the importance of the cancer-associated ECM. Biochemical and physical ECM signals affect tumor formation, invasion, metastasis, and therapy resistance. Examining the tumor microenvironment uncovers intricate ECM dysregulation and interactions with cancer and stromal cells. Anticancer therapies targeting ECM sensors and remodelers, including integrins and matrix metalloproteinases, and ECM-remodeling cells, have seen limited success. This review explores the ECM's role in cancer and discusses potential therapeutic strategies for cell-ECM interactions.
AB - The extracellular matrix (ECM) is essential for cell support during homeostasis and plays a critical role in cancer. Although research often concentrates on the tumor's cellular aspect, attention is growing for the importance of the cancer-associated ECM. Biochemical and physical ECM signals affect tumor formation, invasion, metastasis, and therapy resistance. Examining the tumor microenvironment uncovers intricate ECM dysregulation and interactions with cancer and stromal cells. Anticancer therapies targeting ECM sensors and remodelers, including integrins and matrix metalloproteinases, and ECM-remodeling cells, have seen limited success. This review explores the ECM's role in cancer and discusses potential therapeutic strategies for cell-ECM interactions.
UR - http://www.scopus.com/inward/record.url?scp=85181765826&partnerID=8YFLogxK
U2 - 10.1126/scitranslmed.adg3840
DO - 10.1126/scitranslmed.adg3840
M3 - Review article
C2 - 38170791
AN - SCOPUS:85181765826
SN - 1946-6234
VL - 16
JO - Science Translational Medicine
JF - Science Translational Medicine
IS - 728
M1 - eadg3840
ER -
