TY - JOUR
T1 - The Path towards Predicting Evolution as Illustrated in Yeast Cell Polarity
AU - Daalman, Werner Karl Gustav
AU - Sweep, Els
AU - Laan, Liedewij
PY - 2020
Y1 - 2020
N2 - A bottom-up route towards predicting evolution relies on a deep understanding of the complex network that proteins form inside cells. In a rapidly expanding panorama of experimental possibilities, the most difficult question is how to conceptually approach the disentangling of such complex networks. These can exhibit varying degrees of hierarchy and modularity, which obfuscate certain protein functions that may prove pivotal for adaptation. Using the well-established polarity network in budding yeast as a case study, we first organize current literature to highlight protein entrenchments inside polarity. Following three examples, we see how alternating between experimental novelties and subsequent emerging design strategies can construct a layered understanding, potent enough to reveal evolutionary targets. We show that if you want to understand a cell's evolutionary capacity, such as possible future evolutionary paths, seemingly unimportant proteins need to be mapped and studied. Finally, we generalize this research structure to be applicable to other systems of interest.
AB - A bottom-up route towards predicting evolution relies on a deep understanding of the complex network that proteins form inside cells. In a rapidly expanding panorama of experimental possibilities, the most difficult question is how to conceptually approach the disentangling of such complex networks. These can exhibit varying degrees of hierarchy and modularity, which obfuscate certain protein functions that may prove pivotal for adaptation. Using the well-established polarity network in budding yeast as a case study, we first organize current literature to highlight protein entrenchments inside polarity. Following three examples, we see how alternating between experimental novelties and subsequent emerging design strategies can construct a layered understanding, potent enough to reveal evolutionary targets. We show that if you want to understand a cell's evolutionary capacity, such as possible future evolutionary paths, seemingly unimportant proteins need to be mapped and studied. Finally, we generalize this research structure to be applicable to other systems of interest.
KW - modularity
KW - network evolution
KW - neutrality
KW - polarity
KW - Saccharomyces cerevisiae
KW - symmetry breaking
UR - http://www.scopus.com/inward/record.url?scp=85097035554&partnerID=8YFLogxK
U2 - 10.3390/cells9122534
DO - 10.3390/cells9122534
M3 - Review article
C2 - 33255231
AN - SCOPUS:85097035554
VL - 9
JO - Fuel Cells: from fundamentals to systems
JF - Fuel Cells: from fundamentals to systems
SN - 1615-6846
IS - 12
ER -