The road ahead in clinical network neuroscience

Linda Douw*, Edwin Dellen, van, Alida A. Gouw, Alessandra Griffa, Willem de Haan, Martijn van den Heuvel, Arjan Hillebrand, Piet Van Mieghem, Ida A. Nissen, More Authors

*Corresponding author for this work

Research output: Contribution to journalReview articleScientificpeer-review

17 Citations (Scopus)
32 Downloads (Pure)


Clinical network neuroscience, the study of brain network topology in neurological and psychiatric diseases, has become a mainstay field within clinical neuroscience. Being a multidisciplinary group of clinical network neuroscience experts based in The Netherlands, we often discuss the current state of the art and possible avenues for future investigations. These discussions revolve around questions like “How do dynamic processes alter the underlying structural network?” and “Can we use network neuroscience for disease classification?” This opinion paper is an incomplete overview of these discussions and expands on ten questions that may potentially advance the field. By no means intended as a review of the current state of the field, it is instead meant as a conversation starter and source of inspiration to others.

Original languageEnglish
Pages (from-to)969-993
Number of pages25
JournalNetwork Neuroscience
Issue number4
Publication statusPublished - 2019


  • Clinical application
  • Computational modeling
  • Connectome
  • Graph analysis
  • Network neuroscience
  • Neuroimaging
  • Neurophysiology


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