Plastic energy dissipation is inevitable during fatigue crack growth. There have been previous attempts reported in literature to correlate the plastic dissipated energy (dW/dN) to fatigue crack growth rate (da/dN). However, at a given dW/dN, the da/dN changes with the ratio of minimum and maximum loads, known as the stress ratio. This paper describes an experimental study carried out on 2024-T3 central crack tension specimens to quantify the relation between dW/dN and da/dN. By selecting different stress ratios in the individual tests, the experiments reveal the influence of the stress ratio on this relationship. It is evident that dW/dN has no unique relationship with da/dN valid for the tested stress ratios. Instead, the relationship for each stress ratio is different. This is illustrated with the value of plastic dissipation per unit of fatigue crack growth (dW/da), representing the effective resistance to the crack increment. This value is not a constant, but changes with the stress ratios and da/dN values. Hence the plastic energy dissipation cannot be used directly for predicting crack growth.