Towards Biocatalytic Oxidation of Secondary Alcohols to Carbonyl Products of Relevance for Flavors and Fragrances

Eva Puchľová, T. Hilberath, Kvetoslava Vranková*, F. Hollmann*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Non-enantioselective alcohol dehydrogenases (ADHs) are rarely found in the biocatalysis portfolio. Generally, highly enantioselective ADHs are sought for. Using such ADHs for the oxidation of racemic alcohols generally results in a kinetic resolution of the starting material, which is unfavourable if the ketone represents the product of interest. In the current contribution we report the ADH from Sphingobium yanoikuyae (SyADH) as non-enantioselective ADH for the complete oxidation or rac-heptan-2-ol (representing further 2-alkanols).
Original languageEnglish
Article number926316
Number of pages9
JournalFrontiers in Catalysis
Volume2
DOIs
Publication statusPublished - 2022

Keywords

  • alcohol dehydrogenase
  • deracemisation reactions
  • oxidation reactions
  • biocatalysis
  • Sphingobium yanoikuyae

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