Towards environmentally acceptable synthesis of chiral α-hydroxy ketones via oxidase-lyase cascades

Sandy Schmidt; Tiago Pedroso de Almeida; D Rother; Frank Hollmann

doi:10.1039/C7GC00020K

Towards environmentally acceptable synthesis of chiral α-hydroxy ketones via oxidase-lyase cascades

Sandy Schmidt, Tiago Pedroso de Almeida, D Rother, Frank Hollmann

BT/Biocatalysis

Research output: Contribution to journal › Article › Scientific › peer-review

21 Citations (Scopus)

63 Downloads (Pure)

Abstract

The one-pot multistep enzymatic oxidation of aliphatic and benzylic alcohols to the corresponding aldehydes combined with their subsequent carboligation to chiral α-hydroxy ketones has been exemplarily evaluated in terms of being a “green” biocatalytic approach. Besides the potential to start from bio-derived alcohols, this concept avoids the direct use of the reactive aldehyde intermediates, enables addition of high substrate concentrations in one liquid phase while maintaining enzyme activity and enables a simplified product isolation with diminished waste formation.

Original language	English
Pages (from-to)	1226-1229
Journal	Green Chemistry
Volume	19
Issue number	5
DOIs	https://doi.org/10.1039/C7GC00020K
Publication status	Published - Jan 2017

Access to Document

10.1039/C7GC00020K

c7gc00020kFinal published version, 1.33 MBLicence: CC BY-NC

Cite this

@article{2b73c0b4483f4aae908d9f0799c23e84,

title = "Towards environmentally acceptable synthesis of chiral α-hydroxy ketones via oxidase-lyase cascades",

abstract = "The one-pot multistep enzymatic oxidation of aliphatic and benzylic alcohols to the corresponding aldehydes combined with their subsequent carboligation to chiral α-hydroxy ketones has been exemplarily evaluated in terms of being a “green” biocatalytic approach. Besides the potential to start from bio-derived alcohols, this concept avoids the direct use of the reactive aldehyde intermediates, enables addition of high substrate concentrations in one liquid phase while maintaining enzyme activity and enables a simplified product isolation with diminished waste formation.",

author = "Sandy Schmidt and {Pedroso de Almeida}, Tiago and D Rother and Frank Hollmann",

year = "2017",

month = jan,

doi = "10.1039/C7GC00020K",

language = "English",

volume = "19",

pages = "1226--1229",

journal = "Green Chemistry",

issn = "1463-9262",

publisher = "Royal Society of Chemistry",

number = "5",

}

TY - JOUR

T1 - Towards environmentally acceptable synthesis of chiral α-hydroxy ketones via oxidase-lyase cascades

AU - Schmidt, Sandy

AU - Pedroso de Almeida, Tiago

AU - Rother, D

AU - Hollmann, Frank

PY - 2017/1

Y1 - 2017/1

N2 - The one-pot multistep enzymatic oxidation of aliphatic and benzylic alcohols to the corresponding aldehydes combined with their subsequent carboligation to chiral α-hydroxy ketones has been exemplarily evaluated in terms of being a “green” biocatalytic approach. Besides the potential to start from bio-derived alcohols, this concept avoids the direct use of the reactive aldehyde intermediates, enables addition of high substrate concentrations in one liquid phase while maintaining enzyme activity and enables a simplified product isolation with diminished waste formation.

AB - The one-pot multistep enzymatic oxidation of aliphatic and benzylic alcohols to the corresponding aldehydes combined with their subsequent carboligation to chiral α-hydroxy ketones has been exemplarily evaluated in terms of being a “green” biocatalytic approach. Besides the potential to start from bio-derived alcohols, this concept avoids the direct use of the reactive aldehyde intermediates, enables addition of high substrate concentrations in one liquid phase while maintaining enzyme activity and enables a simplified product isolation with diminished waste formation.

UR - http://resolver.tudelft.nl/uuid:2b73c0b4-483f-4aae-908d-9f0799c23e84

U2 - 10.1039/C7GC00020K

DO - 10.1039/C7GC00020K

M3 - Article

SN - 1463-9262

VL - 19

SP - 1226

EP - 1229

JO - Green Chemistry

JF - Green Chemistry

IS - 5

ER -

Towards environmentally acceptable synthesis of chiral α-hydroxy ketones via oxidase-lyase cascades

Abstract

Access to Document

Other files and links

Fingerprint

Cite this