Towards environmentally acceptable synthesis of chiral α-hydroxy ketones via oxidase-lyase cascades

Sandy Schmidt, Tiago Pedroso de Almeida, D Rother, Frank Hollmann

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)
29 Downloads (Pure)

Abstract

The one-pot multistep enzymatic oxidation of aliphatic and benzylic alcohols to the corresponding aldehydes combined with their subsequent carboligation to chiral α-hydroxy ketones has been exemplarily evaluated in terms of being a “green” biocatalytic approach. Besides the potential to start from bio-derived alcohols, this concept avoids the direct use of the reactive aldehyde intermediates, enables addition of high substrate concentrations in one liquid phase while maintaining enzyme activity and enables a simplified product isolation with diminished waste formation.
Original languageEnglish
Pages (from-to)1226-1229
JournalGreen Chemistry
Volume19
Issue number5
DOIs
Publication statusPublished - Jan 2017

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