Towards environmentally acceptable synthesis of chiral α-hydroxy ketones via oxidase-lyase cascades

Sandy Schmidt; Tiago Pedroso de Almeida; D Rother; Frank Hollmann

doi:10.1039/C7GC00020K

Towards environmentally acceptable synthesis of chiral α-hydroxy ketones via oxidase-lyase cascades

Sandy Schmidt
, Tiago Pedroso de Almeida
, D Rother
, Frank Hollmann

BT/Biocatalysis

Research output: Contribution to journal › Article › Scientific › peer-review

26 Citations (Scopus)

82 Downloads (Pure)

Abstract

The one-pot multistep enzymatic oxidation of aliphatic and benzylic alcohols to the corresponding aldehydes combined with their subsequent carboligation to chiral α-hydroxy ketones has been exemplarily evaluated in terms of being a “green” biocatalytic approach. Besides the potential to start from bio-derived alcohols, this concept avoids the direct use of the reactive aldehyde intermediates, enables addition of high substrate concentrations in one liquid phase while maintaining enzyme activity and enables a simplified product isolation with diminished waste formation.

Original language	English
Pages (from-to)	1226-1229
Journal	Green Chemistry
Volume	19
Issue number	5
DOIs	https://doi.org/10.1039/C7GC00020K
Publication status	Published - Jan 2017

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Towards environmentally acceptable synthesis of chiral α-hydroxy ketones via oxidase-lyase cascades

Abstract

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