Towards Preparative Chemoenzymatic Oxidative Decarboxylation of Glutamic Acid

Xiaomin Xu, Andrada But, Ron Wever, Frank Hollmann

Research output: Contribution to journalArticleScientificpeer-review

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The chemoenzymatic oxidative decarboxylation of glutamic acid to the corresponding nitrile using the vanadium chloroperoxidase from Curvularia inaequalis (CiVCPO) as HOBr generation catalysts has been investigated. Product inhibition was identified as major limitation. Nevertheless, 1630000 turnovers and kcat of 75 s−1 were achieved using 100 mM glutamate. The semi-preparative enzymatic oxidative decarboxylation of glutamate was also demonstrated.

Original languageEnglish
Pages (from-to)2180-2183
Issue number8
Publication statusPublished - 2020


  • biocatalysis
  • glutamic acid
  • nitriles
  • oxidative decarboxylation
  • vanadium chloroperoxidase


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