Current methods to track the progression and evaluate treatment of muscular dystrophies are scarce. The electromechanical delay (EMD), defined as the time lag from muscle electrical activity to motion onset, has been proposed as a biomarker, but provides only limited insight in the pathophysiol-ogy of muscle function. This work proposes and evaluates a novel method to track the propagation of electromechanical waves in muscles, using high density electromyography and ultrafast ultrasound imaging. Muscle contractions in three healthy subjects were evoked by electrical stimulation, and the subsequent propagating action potentials were successfully tracked in all 90 trials. Contractile waves were detected in 83 recordings. Detection rate varied across muscle depth. Mean (SD) velocities for the action potential were 3.71 (0.08) m/s, 4.73 (0.35) m/s and 3.27 (0.09) m/s for participant 1, 2 and 3 respectively. Velocities for the contractile wave were 3.83 (1.07) m/s, 3.32 (0.78) m/s and 3.41 (0.69) m/s for participant 1, 2 and 3 respectively. In conclusion, our technique can track the fast muscular electromechanical dynamics with high spatiotemporal resolution by combining ultrafast ultrasound imaging and high-density electromyography.
|Title of host publication||Proceedings 2019 IEEE International Ultrasonics Symposium, IUS 2019|
|Editors||Sandy Cochran, Margaret Lucas|
|Place of Publication||Pisctaway, NJ, USA|
|Publication status||Published - 2019|
|Event||2019 IEEE International Ultrasonics Symposium, IUS 2019 - Glasgow, United Kingdom|
Duration: 6 Oct 2019 → 9 Oct 2019
|Conference||2019 IEEE International Ultrasonics Symposium, IUS 2019|
|Period||6/10/19 → 9/10/19|
Bibliographical noteGreen Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care
Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.
- excitation-contraction coupling
- high-density electromyography
- ultrafast ultrasound