Transport and metabolism of fumaric acid in Saccharomyces cerevisiae in aerobic glucose-limited chemostat culture

Mihir V. Shah, Oscar van Mastrigt, Joseph J. Heijnen, Walter M. van Gulik

Research output: Contribution to journalArticleScientificpeer-review

3 Citations (Scopus)

Abstract

Currently, research is being focused on the industrial-scale production of fumaric acid and other relevant organic acids from renewable feedstocks via fermentation, preferably at low pH for better product recovery. However, at low pH a large fraction of the extracellular acid is present in the undissociated form, which is lipophilic and can diffuse into the cell. There have been no studies done on the impact of high extracellular concentrations of fumaric acid under aerobic conditions in S. cerevisiae, which is a relevant issue to study for industrial-scale production. In this work we studied the uptake and metabolism of fumaric acid in S. cerevisiae in glucose-limited chemostat cultures at a cultivation pH of 3.0 (pH

Original languageEnglish
Pages (from-to)145-161
Number of pages17
JournalYeast
Volume33
Issue number4
DOIs
Publication statusPublished - 2016

Keywords

  • Fumaric acid
  • Futile cycling
  • Metabolism
  • Permeability coefficient
  • saccharomyces cerevisiae
  • Transport mechanism

Fingerprint Dive into the research topics of 'Transport and metabolism of fumaric acid in Saccharomyces cerevisiae in aerobic glucose-limited chemostat culture'. Together they form a unique fingerprint.

Cite this