Transport and metabolism of fumaric acid in Saccharomyces cerevisiae in aerobic glucose-limited chemostat culture

Mihir V. Shah*, Oscar van Mastrigt, Joseph J. Heijnen, Walter M. van Gulik

*Corresponding author for this work

    Research output: Contribution to journalArticleScientificpeer-review

    4 Citations (Scopus)

    Abstract

    Currently, research is being focused on the industrial-scale production of fumaric acid and other relevant organic acids from renewable feedstocks via fermentation, preferably at low pH for better product recovery. However, at low pH a large fraction of the extracellular acid is present in the undissociated form, which is lipophilic and can diffuse into the cell. There have been no studies done on the impact of high extracellular concentrations of fumaric acid under aerobic conditions in S. cerevisiae, which is a relevant issue to study for industrial-scale production. In this work we studied the uptake and metabolism of fumaric acid in S. cerevisiae in glucose-limited chemostat cultures at a cultivation pH of 3.0 (pH

    Original languageEnglish
    Pages (from-to)145-161
    Number of pages17
    JournalYeast
    Volume33
    Issue number4
    DOIs
    Publication statusPublished - 2016

    Keywords

    • Fumaric acid
    • Futile cycling
    • Metabolism
    • Permeability coefficient
    • saccharomyces cerevisiae
    • Transport mechanism

    Fingerprint

    Dive into the research topics of 'Transport and metabolism of fumaric acid in Saccharomyces cerevisiae in aerobic glucose-limited chemostat culture'. Together they form a unique fingerprint.

    Cite this