Tungsten-Containing Enzymes

Wilfred R. Hagen*

*Corresponding author for this work

Research output: Chapter in Book/Conference proceedings/Edited volumeChapterScientificpeer-review

6 Citations (Scopus)

Abstract

This review on the biochemistry of W-containing enzymes, or tungstoenzymes, starts and ends with the question: "why tungsten'" Structural, kinetic and mechanistic properties of the enzymes are evaluated and related to the common division into two families and several classes. Experimental inconsistencies are identified and proposed models are questioned as a way to determine what we now know and what we still should find out in order to be able to address the "why tungsten'" question in sufficient (bio)chemical depth. Specific recommendations are made to re-direct research on tungstoenzymes in order to cover key dark spots in our present knowledge.

Original languageEnglish
Title of host publicationMolybdenum and Tungsten Enzymes: Biochemistry
EditorsRuss Hille, Carola Schulzke, Martin L. Kirk
PublisherRoyal Society of Chemistry
Pages313-342
Number of pages30
ISBN (Print)978-1-78262-089-1
DOIs
Publication statusPublished - 2017

Publication series

NameRSC Metallobiology
Number5
Volume2017-January
ISSN (Print)2045547X

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