Two-Step Radionuclide Tumor Targeting through Bioorthogonal Mechanism using SPIONs

Radiation therapy has made tremendous progress in oncology over the last decades due to advances in engineering and physical sciences in combination with better biochemical, genetic and molecular understanding of this disease. Local delivery of optimal radiation dose to a tumor, while sparing healthy surrounding tissues, remains a great challenge, especially in the proximity of vital organs. Therefore, imaging plays a key role in tumor staging, accurate target volume delineation, assessment of individual radiation resistance, and even personalized dose prescription. From this point of view, radiation therapy (both external and internal) might be one of the few therapeutic modalities that relies entirely on high-resolution imaging...