Uncertainty Assessment of a Hybrid Cell-Continuum Based Model for Wound Contraction

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Abstract

We assess the uncertainty in a hybrid cell-based, continuum-based model for wound contraction. We explore the correlations between the final contraction of a wound and the stiffness of the tissue, forcing applied by fibroblasts, plastic forces, death rate of cells, differentiation rate of cells, amount of random walk, and the chemotactic strength. Furthermore, we compute the likelihood that serious contractions occur. Although the current model is very simple, the principles can be used to unravel the most important biological mechanisms behind wound contraction.

Original languageEnglish
Title of host publicationNumerical Mathematics and Advanced Applications ENUMATH 2017
EditorsFlorin Adrian Radu, Kundan Kumar, Inga Berre, Jan Martin Nordbotten, Iuliu Sorin Pop
Place of PublicationCham
PublisherSpringer
Pages247-255
Number of pages9
ISBN (Electronic)978-3-319-96415-7
ISBN (Print)978-3-319-96414-0
DOIs
Publication statusPublished - 2019
EventENUMATH 2017: European Conference on Numerical Mathematics and Advanced Applications - University of Bergen, Voss, Norway
Duration: 25 Sep 201729 Sep 2017
https://www.uib.no/en/enumath2017

Publication series

NameLecture Notes in Computational Science and Engineering
Volume126
ISSN (Print)1439-7358

Conference

ConferenceENUMATH 2017
CountryNorway
CityVoss
Period25/09/1729/09/17
Internet address

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  • Cite this

    Vermolen, F. (2019). Uncertainty Assessment of a Hybrid Cell-Continuum Based Model for Wound Contraction. In F. A. Radu, K. Kumar, I. Berre, J. M. Nordbotten, & I. S. Pop (Eds.), Numerical Mathematics and Advanced Applications ENUMATH 2017 (pp. 247-255). (Lecture Notes in Computational Science and Engineering; Vol. 126). Springer. https://doi.org/10.1007/978-3-319-96415-7_21