Uncompromised ten-year survival of oldest old carrying somatic mutations in DNMT3A and TET2

Erik van den Akker; Steven J. Pitts; JB van Meurs; M Beekman; Marcel Reinders; PE Slagboom

Uncompromised ten-year survival of oldest old carrying somatic mutations in DNMT3A and TET2

Erik van den Akker, Steven J. Pitts, JB van Meurs, M Beekman, Marcel Reinders, PE Slagboom

Pattern Recognition and Bioinformatics

Research output: Contribution to conference › Poster › Scientific

Abstract

Recent large-scale sequencing studies report recurrent somatic mutations in the blood of elderly individuals in genes previously linked to clonal expansion of hematopoietic stem cells [1-4]. Particularly for DNMT3A and TET2, a steep ageassociated increase in the prevalence of somatic mutations is observed from middle age onward [2-4]. In addition, prospective analyses performed in predominantly middle-aged individuals show an increased risk for all-cause mortality for carriers of such mutations as compared with non-carriers [3,4]. Jointly, these data suggest a rapidly increasing vulnerability among the elderly for adverse health effects associated with clonal expansion of hematopoietic stem cells.

Original language	English
Pages	1-1
Number of pages	1
Publication status	Published - 17 Mar 2016

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title = "Uncompromised ten-year survival of oldest old carrying somatic mutations in DNMT3A and TET2",

abstract = "Recent large-scale sequencing studies report recurrent somatic mutations in the blood of elderly individuals in genes previously linked to clonal expansion of hematopoietic stem cells [1-4]. Particularly for DNMT3A and TET2, a steep ageassociated increase in the prevalence of somatic mutations is observed from middle age onward [2-4]. In addition, prospective analyses performed in predominantly middle-aged individuals show an increased risk for all-cause mortality for carriers of such mutations as compared with non-carriers [3,4]. Jointly, these data suggest a rapidly increasing vulnerability among the elderly for adverse health effects associated with clonal expansion of hematopoietic stem cells.",

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T1 - Uncompromised ten-year survival of oldest old carrying somatic mutations in DNMT3A and TET2

AU - van den Akker, Erik

AU - Pitts, Steven J.

AU - van Meurs, JB

AU - Beekman, M

AU - Reinders, Marcel

AU - Slagboom, PE

PY - 2016/3/17

Y1 - 2016/3/17

N2 - Recent large-scale sequencing studies report recurrent somatic mutations in the blood of elderly individuals in genes previously linked to clonal expansion of hematopoietic stem cells [1-4]. Particularly for DNMT3A and TET2, a steep ageassociated increase in the prevalence of somatic mutations is observed from middle age onward [2-4]. In addition, prospective analyses performed in predominantly middle-aged individuals show an increased risk for all-cause mortality for carriers of such mutations as compared with non-carriers [3,4]. Jointly, these data suggest a rapidly increasing vulnerability among the elderly for adverse health effects associated with clonal expansion of hematopoietic stem cells.

AB - Recent large-scale sequencing studies report recurrent somatic mutations in the blood of elderly individuals in genes previously linked to clonal expansion of hematopoietic stem cells [1-4]. Particularly for DNMT3A and TET2, a steep ageassociated increase in the prevalence of somatic mutations is observed from middle age onward [2-4]. In addition, prospective analyses performed in predominantly middle-aged individuals show an increased risk for all-cause mortality for carriers of such mutations as compared with non-carriers [3,4]. Jointly, these data suggest a rapidly increasing vulnerability among the elderly for adverse health effects associated with clonal expansion of hematopoietic stem cells.

UR - http://bioinformatics.ewi.tudelft.nl/sites/default/files/poster_erikvandenakker-2016.pdf

M3 - Poster

SP - 1

EP - 1

ER -

Uncompromised ten-year survival of oldest old carrying somatic mutations in DNMT3A and TET2

Abstract

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