Uncompromised ten-year survival of oldest old carrying somatic mutations in DNMT3A and TET2

Erik van den Akker, Steven J. Pitts, JB van Meurs, M Beekman, Marcel Reinders, PE Slagboom

Research output: Contribution to conferencePosterScientific

Abstract

Recent large-scale sequencing studies report recurrent somatic mutations in the blood of elderly individuals in genes previously linked to clonal expansion of hematopoietic stem cells [1-4]. Particularly for DNMT3A and TET2, a steep ageassociated increase in the prevalence of somatic mutations is observed from middle age onward [2-4]. In addition, prospective analyses performed in predominantly middle-aged individuals show an increased risk for all-cause mortality for carriers of such mutations as compared with non-carriers [3,4]. Jointly, these data suggest a rapidly increasing vulnerability among the elderly for adverse health effects associated with clonal expansion of hematopoietic stem cells.
Original languageEnglish
Pages1-1
Number of pages1
Publication statusPublished - 17 Mar 2016

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