Unlocking the potential of cultivated meat through cell line engineering

Camilo Riquelme-Guzmán; Andrew J. Stout; David L. Kaplan; Joshua E. Flack

doi:10.1016/j.isci.2024.110877

Unlocking the potential of cultivated meat through cell line engineering

Camilo Riquelme-Guzmán, Andrew J. Stout, David L. Kaplan, Joshua E. Flack^*

^*Corresponding author for this work

BT/Bioprocess Engineering

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

Cultivated meat has the potential to revolutionize food production, but its progress is hindered by fundamental shortcomings of mammalian cells with respect to industrial-scale bioprocesses. Here, we discuss the essential role of cell line engineering in overcoming these limitations, highlighting the balance between the benefits of enhanced cellular traits and the associated regulatory and consumer acceptance challenges. We believe that careful selection of cell engineering strategies, including both genetic and non-genetic modifications, can address this trade-off and is essential to advancing the field.

Original language	English
Article number	110877
Number of pages	8
Journal	iScience
Volume	27
Issue number	10
DOIs	https://doi.org/10.1016/j.isci.2024.110877
Publication status	Published - 2024

Keywords

Applied sciences
Biotechnology
Food biotechnology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.isci.2024.110877

1-s2.0-S2589004224021023-mainFinal published version, 2.5 MBLicence: CC BY

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abstract = "Cultivated meat has the potential to revolutionize food production, but its progress is hindered by fundamental shortcomings of mammalian cells with respect to industrial-scale bioprocesses. Here, we discuss the essential role of cell line engineering in overcoming these limitations, highlighting the balance between the benefits of enhanced cellular traits and the associated regulatory and consumer acceptance challenges. We believe that careful selection of cell engineering strategies, including both genetic and non-genetic modifications, can address this trade-off and is essential to advancing the field.",

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AU - Kaplan, David L.

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PY - 2024

Y1 - 2024

N2 - Cultivated meat has the potential to revolutionize food production, but its progress is hindered by fundamental shortcomings of mammalian cells with respect to industrial-scale bioprocesses. Here, we discuss the essential role of cell line engineering in overcoming these limitations, highlighting the balance between the benefits of enhanced cellular traits and the associated regulatory and consumer acceptance challenges. We believe that careful selection of cell engineering strategies, including both genetic and non-genetic modifications, can address this trade-off and is essential to advancing the field.

AB - Cultivated meat has the potential to revolutionize food production, but its progress is hindered by fundamental shortcomings of mammalian cells with respect to industrial-scale bioprocesses. Here, we discuss the essential role of cell line engineering in overcoming these limitations, highlighting the balance between the benefits of enhanced cellular traits and the associated regulatory and consumer acceptance challenges. We believe that careful selection of cell engineering strategies, including both genetic and non-genetic modifications, can address this trade-off and is essential to advancing the field.

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KW - Biotechnology

KW - Food biotechnology

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Unlocking the potential of cultivated meat through cell line engineering

Abstract

Keywords

UN SDGs

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