Unraveling energy homeostasis in a dynamic model of glycolysis in Escherichia coli

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Abstract

We study dynamic metabolic models that describe the cellular responses of microorganisms under changing environmental conditions, such as substrate perturbations. Feast-famine experiments in Escherichia coli show that, despite the enormous extracellular perturbations, important quantities such as the cell energy charge remain practically constant. We propose a simplified kinetic model of glycolysis in E. coli and we analyse it to investigate the mechanisms that guarantee the observed homeostatic energy charge. Identifying the source of this extraordinary robustness will streamline the synthesis of robust and efficient “cell factories” for the production of relevant chemicals, enabling sustainable processes.
Original languageEnglish
Title of host publicationProceedings of the 18th European Control Conference (ECC 2019)
Place of PublicationPisacataway, NJ, USA
PublisherIEEE
Pages2140-2145
ISBN (Print)978-3-907144-00-8
DOIs
Publication statusPublished - 2019
EventECC 2019: 18th European Control Conference - Napoli, Italy
Duration: 25 Jun 201928 Jun 2019

Conference

ConferenceECC 2019: 18th European Control Conference
CountryItaly
CityNapoli
Period25/06/1928/06/19

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