Visual Analysis of Tumor Control Models for Prediction of Radiotherapy Response

Renata Georgia Raidou, O. Casares-Magaz, L.P. Muren, UA van der Heide, J. Rørvik, Marcel J. Breeuwer, Anna Vilanova Bartroli

Research output: Contribution to journalArticleScientificpeer-review

12 Citations (Scopus)

Abstract

In radiotherapy, tumors are irradiated with a high dose, while surrounding healthy tissues are spared. To quantify the probability that a tumor is effectively treated with a given dose, statistical models were built and employed in clinical research. These are called tumor control probability (TCP) models. Recently, TCP models started incorporating additional information from imaging modalities. In this way, patient-specific properties of tumor tissues are included, improving the radiobiological accuracy of models. Yet, the employed imaging modalities are subject to uncertainties with significant impact on the modeling outcome, while the models are sensitive to a number of parameter assumptions. Currently, uncertainty and parameter sensitivity are not incorporated in the analysis, due to time and resource constraints. To this end, we propose a visual tool that enables clinical researchers working on TCP modeling, to explore the information provided by their models, to discover new knowledge and to confirm or generate hypotheses within their data. Our approach incorporates the following four main components: (1) It supports the exploration of uncertainty and its effect on TCP models; (2) It facilitates parameter sensitivity analysis to common assumptions; (3) It enables the identification of inter-patient response variability; (4) It allows starting the analysis from the desired treatment outcome, to identify treatment strategies that achieve it. We conducted an evaluation with nine clinical researchers. All participants agreed that the proposed visual tool provides better understanding and new opportunities for the exploration and analysis of TCP modeling.
Original languageEnglish
Pages (from-to)231-240
Number of pages10
JournalComputer Graphics Forum (online)
Volume35
Issue number3
DOIs
Publication statusPublished - 2016
EventEuroVis 2016: 18th EG/VGTC Conference on Visualization - Groningen, Netherlands
Duration: 6 Jun 201610 Jun 2016

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