Visual seizure annotation and automated seizure detection using behind-the-ear electroencephalographic channels

Kaat Vandecasteele, Thomas De Cooman, Jonathan Dan, Evy Cleeren, Sabine Van Huffel, Borbála Hunyadi, Wim Van Paesschen

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Abstract

Objective: Seizure diaries kept by patients are unreliable. Automated electroencephalography (EEG)-based seizure detection systems are a useful support tool to objectively detect and register seizures during long-term video-EEG recording. However, this standard full scalp-EEG recording setup is of limited use outside the hospital, and a discreet, wearable device is needed for capturing seizures in the home setting. We are developing a wearable device that records EEG with behind-the-ear electrodes. In this study, we determined whether the recognition of ictal patterns using only behind-the-ear EEG channels is possible. Second, an automated seizure detection algorithm was developed using only those behind-the-ear EEG channels. Methods: Fifty-four patients with a total of 182 seizures, mostly temporal lobe epilepsy (TLE), and 5284 hours of data, were recorded with a standard video-EEG at University Hospital Leuven. In addition, extra behind-the-ear EEG channels were recorded. First, a neurologist was asked to annotate behind-the-ear EEG segments containing selected seizure and nonseizure fragments. Second, a data-driven algorithm was developed using only behind-the-ear EEG. This algorithm was trained using data from other patients (patient-independent model) or from the same patient (patient-specific model). Results: The visual recognition study resulted in 65.7% sensitivity and 94.4% specificity. By using those seizure annotations, the automated algorithm obtained 64.1% sensitivity and 2.8 false-positive detections (FPs)/24 hours with the patient-independent model. The patient-specific model achieved 69.1% sensitivity and 0.49 FPs/24 hours. Significance: Visual recognition of ictal EEG patterns using only behind-the-ear EEG is possible in a significant number of patients with TLE. A patient-specific seizure detection algorithm using only behind-the-ear EEG was able to detect more seizures automatically than what patients typically report, with 0.49 FPs/24 hours. We conclude that a large number of refractory TLE patients can benefit from using this device.

Original languageEnglish
Pages (from-to)766-775
Number of pages10
JournalEpilepsia
Volume61
Issue number4
DOIs
Publication statusPublished - 2020

Keywords

  • automated algorithms
  • behind-the-ear EEG
  • epilepsy
  • reduced electrode montage
  • seizure detection
  • wearable sensors

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    Vandecasteele, K., De Cooman, T., Dan, J., Cleeren, E., Van Huffel, S., Hunyadi, B., & Van Paesschen, W. (2020). Visual seizure annotation and automated seizure detection using behind-the-ear electroencephalographic channels. Epilepsia, 61(4), 766-775. https://doi.org/10.1111/epi.16470