Wafer-Scale Graphene-Based Soft Electrode Array with Optogenetic Compatibility

A.I. Velea; S. Vollebregt; G.K. Wardhana; V. Giagka

doi:10.1109/MEMS46641.2020.9056367

Wafer-Scale Graphene-Based Soft Electrode Array with Optogenetic Compatibility

A.I. Velea, S. Vollebregt, G.K. Wardhana, V. Giagka

Research output: Chapter in Book/Conference proceedings/Edited volume › Conference contribution › Scientific › peer-review

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Abstract

This paper reports on the characterization of a microfabricated wafer-scale, graphene-based, soft implant for spinal cord applications. Graphene is used because of its high transparency and good conductivity, making it suitable for optogenetic applications. Moreover it has a high mechanical strength and is potentially biocompatible. The implant consists of multi-layered chemical vapor deposited graphene, in the form of electrodes and tracks, encapsulated between 2 layers of silicone. Methods such as Raman spectroscopy, optical transmittance, and electrical measurements combined with bending tests and in-vitro experiments, using phosphate-buffered saline (PBS) solution, were employed to characterize the device. The results have shown high bendability and no critical damage of the graphene after immersing the device in PBS solution up to 7 days. To the authors' best knowledge, this is the first work that presents a soft and fully scalable optogenetics-compatible graphene-based spinal cord electrode array.

Original language	English
Title of host publication	33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020
Place of Publication	Vancouver, Canada
Publisher	IEEE Sensors
Pages	421-424
Number of pages	4
ISBN (Electronic)	9781728135809
ISBN (Print)	978-1-7281-3581-6
DOIs	https://doi.org/10.1109/MEMS46641.2020.9056367
Publication status	Published - 2020
Event	33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020 - Vancouver, Canada Duration: 18 Jan 2020 → 22 Jan 2020 Conference number: 33 https://www.mems20.org

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume	2020-January
ISSN (Print)	1084-6999

Conference

Conference	33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020
Abbreviated title	MEMS 2020
Country/Territory	Canada
City	Vancouver
Period	18/01/20 → 22/01/20
Internet address	https://www.mems20.org

Keywords

Wafer-scale implant
graphene
optogenetic compatibility
silicone

Access to Document

10.1109/MEMS46641.2020.9056367

PID6258295-Wafer-scalegraphene-basedsoftelectrodearraywithoptogeneticcompatibilityAccepted author manuscript, 7.68 MB

Cite this

Velea, A. I., Vollebregt, S., Wardhana, G. K., & Giagka, V. (2020). Wafer-Scale Graphene-Based Soft Electrode Array with Optogenetic Compatibility. In 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020 (pp. 421-424). Article 9056367 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2020-January). IEEE Sensors. https://doi.org/10.1109/MEMS46641.2020.9056367

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title = "Wafer-Scale Graphene-Based Soft Electrode Array with Optogenetic Compatibility",

abstract = "This paper reports on the characterization of a microfabricated wafer-scale, graphene-based, soft implant for spinal cord applications. Graphene is used because of its high transparency and good conductivity, making it suitable for optogenetic applications. Moreover it has a high mechanical strength and is potentially biocompatible. The implant consists of multi-layered chemical vapor deposited graphene, in the form of electrodes and tracks, encapsulated between 2 layers of silicone. Methods such as Raman spectroscopy, optical transmittance, and electrical measurements combined with bending tests and in-vitro experiments, using phosphate-buffered saline (PBS) solution, were employed to characterize the device. The results have shown high bendability and no critical damage of the graphene after immersing the device in PBS solution up to 7 days. To the authors' best knowledge, this is the first work that presents a soft and fully scalable optogenetics-compatible graphene-based spinal cord electrode array.",

keywords = "Wafer-scale implant, graphene, optogenetic compatibility, silicone",

author = "A.I. Velea and S. Vollebregt and G.K. Wardhana and V. Giagka",

year = "2020",

doi = "10.1109/MEMS46641.2020.9056367",

language = "English",

isbn = "978-1-7281-3581-6",

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publisher = "IEEE Sensors",

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Velea, AI, Vollebregt, S, Wardhana, GK & Giagka, V 2020, Wafer-Scale Graphene-Based Soft Electrode Array with Optogenetic Compatibility. in 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020., 9056367, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), vol. 2020-January, IEEE Sensors, Vancouver, Canada, pp. 421-424, 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020, Vancouver, Canada, 18/01/20. https://doi.org/10.1109/MEMS46641.2020.9056367

Wafer-Scale Graphene-Based Soft Electrode Array with Optogenetic Compatibility. / Velea, A.I.; Vollebregt, S.; Wardhana, G.K. et al.
33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020. Vancouver, Canada: IEEE Sensors, 2020. p. 421-424 9056367 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2020-January).

Research output: Chapter in Book/Conference proceedings/Edited volume › Conference contribution › Scientific › peer-review

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N2 - This paper reports on the characterization of a microfabricated wafer-scale, graphene-based, soft implant for spinal cord applications. Graphene is used because of its high transparency and good conductivity, making it suitable for optogenetic applications. Moreover it has a high mechanical strength and is potentially biocompatible. The implant consists of multi-layered chemical vapor deposited graphene, in the form of electrodes and tracks, encapsulated between 2 layers of silicone. Methods such as Raman spectroscopy, optical transmittance, and electrical measurements combined with bending tests and in-vitro experiments, using phosphate-buffered saline (PBS) solution, were employed to characterize the device. The results have shown high bendability and no critical damage of the graphene after immersing the device in PBS solution up to 7 days. To the authors' best knowledge, this is the first work that presents a soft and fully scalable optogenetics-compatible graphene-based spinal cord electrode array.

AB - This paper reports on the characterization of a microfabricated wafer-scale, graphene-based, soft implant for spinal cord applications. Graphene is used because of its high transparency and good conductivity, making it suitable for optogenetic applications. Moreover it has a high mechanical strength and is potentially biocompatible. The implant consists of multi-layered chemical vapor deposited graphene, in the form of electrodes and tracks, encapsulated between 2 layers of silicone. Methods such as Raman spectroscopy, optical transmittance, and electrical measurements combined with bending tests and in-vitro experiments, using phosphate-buffered saline (PBS) solution, were employed to characterize the device. The results have shown high bendability and no critical damage of the graphene after immersing the device in PBS solution up to 7 days. To the authors' best knowledge, this is the first work that presents a soft and fully scalable optogenetics-compatible graphene-based spinal cord electrode array.

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Velea AI, Vollebregt S, Wardhana GK , Giagka V. Wafer-Scale Graphene-Based Soft Electrode Array with Optogenetic Compatibility. In 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020. Vancouver, Canada: IEEE Sensors. 2020. p. 421-424. 9056367. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMS46641.2020.9056367

Wafer-Scale Graphene-Based Soft Electrode Array with Optogenetic Compatibility

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