Water-Soluble Anthraquinone Photocatalysts Enable Methanol-Driven Enzymatic Halogenation and Hydroxylation Reactions

Bo Yuan, Durga Mahor, Qiang Fei, Ron Wever, Miguel Alcalde, Wuyuan Zhang, Frank Hollmann

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Peroxyzymes simply use H2O2 as a cosubstrate to oxidize a broad range of inert C-H bonds. The lability of many peroxyzymes against H2O2 can be addressed by a controlled supply of H2O2, ideally in situ. Here, we report a simple, robust, and water-soluble anthraquinone sulfonate (SAS) as a promising organophotocatalyst to drive both haloperoxidase-catalyzed halogenation and peroxygenase-catalyzed oxyfunctionalization reactions. Simple alcohols, methanol in particular, can be used both as a cosolvent and an electron donor for H2O2 generation. Very promising turnover numbers for the biocatalysts of up to 318 »000 have been achieved.

Original languageEnglish
Pages (from-to)8277-8284
JournalACS Catalysis
Volume10
Issue number15
DOIs
Publication statusPublished - 2020

Keywords

  • HOgeneration
  • halogenation
  • hydroxylation
  • peroxyzymes
  • photobiocatalysis

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