What makes long DNA short? Modulation of DNA structure by Dps protein: cooperating & reorganizing

Natalia Vtyurina

    Research output: ThesisDissertation (TU Delft)

    82 Downloads (Pure)

    Abstract

    Each confined cell created by nature and containing DNA molecule falls into the category of “alive organism”. All information about this organism is encoded in DNA molecule in genes, except of fate only. Along with the DNA molecule that represents genetic carrier, the organism neither the genome could function without proteins. Proteins are the building blocks from which cells are assembled and capable of activating or disabling particular genes playing a crucial role in DNA replication, repair and protection. In order to understand the function of each singular protein and its role in the overall cellular metabolism, we need to characterize it from different perspectives. Without this knowledge, we do not possess a complete picture of the vitally important processes in the cell and might be losing a very promising pipeline for a treatment of many diseases.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • Delft University of Technology
    Supervisors/Advisors
    • Dekker, N.H., Supervisor
    • Abbondanzieri, Elio, Advisor
    Award date9 Sept 2016
    Print ISBNs978-90-8593-262-8
    DOIs
    Publication statusPublished - 2016

    Keywords

    • single-molecule
    • DNA condensation
    • Dps protein
    • cooperativity
    • reorganization
    • hysteresis
    • Ising model

    Fingerprint

    Dive into the research topics of 'What makes long DNA short? Modulation of DNA structure by Dps protein: cooperating & reorganizing'. Together they form a unique fingerprint.

    Cite this