%PDF-1.6
%
1 0 obj
<<
/AcroForm 2 0 R
/Lang (EN)
/Metadata 3 0 R
/Names 4 0 R
/OpenAction [5 0 R /Fit]
/Outlines 6 0 R
/OutputIntents [7 0 R]
/PageLabels 8 0 R
/PageMode /UseOutlines
/Pages 9 0 R
/Type /Catalog
>>
endobj
10 0 obj
<<
/Author (Jiao Chen )
/CreationDate (D:20180529132541+05'30')
/Creator (Springer)
/CrossMarkDomains#5B1#5D (springer.com)
/CrossMarkDomains#5B2#5D (springerlink.com)
/CrossmarkDomainExclusive (true)
/CrossmarkMajorVersionDate (2010-04-23)
/Keywords (Cell deformation,Nucleus deformation,Monte Carlo simulations,Cancer metastasis,Cell-based model)
/ModDate (D:20180912161748+05'30')
/Producer (Acrobat Distiller 10.1.8 \(Windows\))
/Subject (Biomechanics and Modeling in Mechanobiology, https://doi.org/10.1007/s10237-018-1036-5)
/Title (A phenomenological model for cell and nucleus deformation during cancer metastasis)
/doi (10.1007/s10237-018-1036-5)
/robots (noindex)
>>
endobj
2 0 obj
<<
/DA (/Helv 0 Tf 0 g )
/DR <<
/Encoding <<
/PDFDocEncoding 11 0 R
>>
/Font <<
/Helv 12 0 R
/ZaDb 13 0 R
>>
>>
/Fields []
>>
endobj
3 0 obj
<<
/Length 31081
/Subtype /XML
/Type /Metadata
>>
stream
2018-05-29T13:25:41+05:30
Springer
2018-09-12T16:17:48+05:30
2018-09-12T16:17:48+05:30
Acrobat Distiller 10.1.8 (Windows)
Cell deformation,Nucleus deformation,Monte Carlo simulations,Cancer metastasis,Cell-based model
application/pdf
https://doi.org/10.1007/s10237-018-1036-5
Springer Berlin Heidelberg
Biomechanics and Modeling in Mechanobiology, https://doi.org/10.1007/s10237-018-1036-5
Cell deformation
Nucleus deformation
Monte Carlo simulations
Cancer metastasis
Cell-based model
A phenomenological model for cell and nucleus deformation during cancer metastasis
Jiao Chen
Daphne Weihs
Marcel Van Dijk
Fred J. Vermolen
10.1007/s10237-018-1036-5
2010-04-23
true
springer.com
springerlink.com
https://doi.org/10.1007/s10237-018-1036-5
10.1007/s10237-018-1036-5
1617-7940
17
5
1429
1450
journal
Biomechanics and Modeling in Mechanobiology
The Author(s)
2010-04-23
true
10.1007/s10237-018-1036-5
noindex
springer.com
springerlink.com
VoR
uuid:05c1ff46-b756-41fb-ad06-be9ea273e451
uuid:b9c56fcd-7017-4c51-8065-781bc576cce7
default
1
converted
uuid:bfcbd8e1-e4e0-4e08-975b-9618025a1aaa
converted to PDF/A-2b
pdfToolbox
2018-09-12T16:14:34+05:30
converted
uuid:0267bb7f-3874-4b69-8a24-72687eccda8c
converted to PDF/A-2b
pdfToolbox
2018-09-12T16:17:48+05:30
2
B
Jiao Chen
http://orcid.org/0000-0002-4033-5636
http://ns.adobe.com/pdfx/1.3/
pdfx
Adobe Document Info PDF eXtension Schema
external
Mirrors crossmark:MajorVersionDate
CrossmarkMajorVersionDate
Text
external
Mirrors crossmark:CrossmarkDomainExclusive
CrossmarkDomainExclusive
Text
internal
Mirrors crossmark:DOI
doi
Text
external
Mirrors crossmark:CrosMarkDomains
CrossMarkDomains
seq Text
internal
A name object indicating whether the document has been modified to include trapping information
robots
Text
internal
ID of PDF/X standard
GTS_PDFXVersion
Text
internal
Conformance level of PDF/X standard
GTS_PDFXConformance
Text
internal
Company creating the PDF
Company
Text
internal
Date when document was last modified
SourceModified
Text
http://crossref.org/crossmark/1.0/
crossmark
Crossmark Schema
internal
Usual same as prism:doi
DOI
Text
external
The date when a publication was publishe.
MajorVersionDate
Text
internal
CrossmarkDomainExclusive
CrossmarkDomainExclusive
Text
internal
CrossMarkDomains
CrossMarkDomains
seq Text
http://prismstandard.org/namespaces/basic/2.0/
prism
Prism Schema
external
This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.
url
URI
external
The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL).
doi
Text
external
ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.
issn
Text
internal
Volume number
volume
Text
internal
Issue number
number
Text
internal
Starting page
startingPage
Text
internal
Ending page
endingPage
Text
external
The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary.
aggregationType
Text
external
Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”
publicationName
Text
external
Copyright
copyright
Text
http://ns.adobe.com/pdf/1.3/
pdf
Adobe PDF Schema
internal
A name object indicating whether the document has been modified to include trapping information
Trapped
Text
http://ns.adobe.com/xap/1.0/mm/
xmpMM
XMP Media Management Schema
internal
UUID based identifier for specific incarnation of a document
InstanceID
URI
internal
The common identifier for all versions and renditions of a document.
DocumentID
URI
internal
The common identifier for all versions and renditions of a document.
OriginalDocumentID
URI
http://www.aiim.org/pdfa/ns/id/
pdfaid
PDF/A ID Schema
internal
Part of PDF/A standard
part
Integer
internal
Amendment of PDF/A standard
amd
Text
internal
Conformance level of PDF/A standard
conformance
Text
Springer Nature ORCID Schema
http://springernature.com/ns/xmpExtensions/2.0/
sn
authorInfo
Bag AuthorInformation
external
Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.
AuthorInformation
http://springernature.com/ns/xmpExtensions/2.0/authorInfo/
author
Specifies the types of author information: name and ORCID of an author.
name
Text
Gives the name of an author.
orcid
URI
Gives the ORCID of an author.
http://www.niso.org/schemas/jav/1.0/
jav
NISO
external
Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record
journal_article_version
Closed Choice of Text
endstream
endobj
4 0 obj
<<
/Dests 14 0 R
>>
endobj
5 0 obj
<<
/Annots [15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R
25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R
35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R]
/Contents [45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R]
/CropBox [0.0 0.0 595.276 790.866]
/MediaBox [0.0 0.0 595.276 790.866]
/Parent 53 0 R
/Resources 54 0 R
/Rotate 0
/Thumb 55 0 R
/Type /Page
>>
endobj
6 0 obj
<<
/First 56 0 R
/Last 56 0 R
/Type /Outlines
>>
endobj
7 0 obj
<<
/DestOutputProfile 57 0 R
/Info (sRGB IEC61966-2.1)
/OutputCondition (sRGB)
/OutputConditionIdentifier (Custom)
/RegistryName ()
/S /GTS_PDFA1
/Type /OutputIntent
>>
endobj
8 0 obj
<<
/Nums [0 58 0 R]
>>
endobj
9 0 obj
<<
/Count 23
/Kids [53 0 R 59 0 R 60 0 R]
/Type /Pages
>>
endobj
11 0 obj
<<
/Differences [24 /breve /caron /circumflex /dotaccent /hungarumlaut /ogonek /ring /tilde 39
/quotesingle 96 /grave 128 /bullet /dagger /daggerdbl /ellipsis /emdash /endash
/florin /fraction /guilsinglleft /guilsinglright /minus /perthousand /quotedblbase /quotedblleft /quotedblright /quoteleft
/quoteright /quotesinglbase /trademark /fi /fl /Lslash /OE /Scaron /Ydieresis /Zcaron
/dotlessi /lslash /oe /scaron /zcaron 160 /Euro 164 /currency 166
/brokenbar 168 /dieresis /copyright /ordfeminine 172 /logicalnot /.notdef /registered /macron
/degree /plusminus /twosuperior /threesuperior /acute /mu 183 /periodcentered /cedilla /onesuperior
/ordmasculine 188 /onequarter /onehalf /threequarters 192 /Agrave /Aacute /Acircumflex /Atilde
/Adieresis /Aring /AE /Ccedilla /Egrave /Eacute /Ecircumflex /Edieresis /Igrave /Iacute
/Icircumflex /Idieresis /Eth /Ntilde /Ograve /Oacute /Ocircumflex /Otilde /Odieresis /multiply
/Oslash /Ugrave /Uacute /Ucircumflex /Udieresis /Yacute /Thorn /germandbls /agrave /aacute
/acircumflex /atilde /adieresis /aring /ae /ccedilla /egrave /eacute /ecircumflex /edieresis
/igrave /iacute /icircumflex /idieresis /eth /ntilde /ograve /oacute /ocircumflex /otilde
/odieresis /divide /oslash /ugrave /uacute /ucircumflex /udieresis /yacute /thorn /ydieresis]
/Type /Encoding
>>
endobj
12 0 obj
<<
/BaseFont /Helvetica
/Encoding 11 0 R
/Name /Helv
/Subtype /Type1
/Type /Font
>>
endobj
13 0 obj
<<
/BaseFont /ZapfDingbats
/Name /ZaDb
/Subtype /Type1
/Type /Font
>>
endobj
14 0 obj
<<
/Kids [61 0 R 62 0 R 63 0 R]
>>
endobj
15 0 obj
<<
/A <<
/S /URI
/URI (http://crossmark.crossref.org/dialog/?doi=10.1007/s10237-018-1036-5&domain=pdf)
>>
/AP <<
/N 64 0 R
>>
/Border [0 0 0]
/C [0 1 1]
/F 4
/H /I
/Rect [485.073 695.865 546.069 721.851]
/Subtype /Link
/Type /Annot
>>
endobj
16 0 obj
<<
/A <<
/S /URI
/URI (http://orcid.org/0000-0002-4033-5636)
>>
/AP <<
/N 65 0 R
>>
/Border [0 0 0]
/C [0 1 1]
/F 4
/H /I
/Rect [97.452 621.228 108.444 632.22]
/Subtype /Link
/Type /Annot
>>
endobj
17 0 obj
<<
/AP <<
/N 66 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.lauffenburger1996cell)
/F 4
/H /I
/Rect [288.144 281.712 289.14 293.169]
/Subtype /Link
/Type /Annot
>>
endobj
18 0 obj
<<
/AP <<
/N 67 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.lauffenburger1996cell)
/F 4
/H /I
/Rect [50.04 269.256 70.944 280.713]
/Subtype /Link
/Type /Annot
>>
endobj
19 0 obj
<<
/AP <<
/N 68 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.chambers2002metastasis)
/F 4
/H /I
/Rect [169.794 231.897 170.79 243.354]
/Subtype /Link
/Type /Annot
>>
endobj
20 0 obj
<<
/AP <<
/N 69 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.chambers2002metastasis)
/F 4
/H /I
/Rect [175.59 231.897 201.471 243.354]
/Subtype /Link
/Type /Annot
>>
endobj
21 0 obj
<<
/AP <<
/N 70 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.fidler2003pathogenesis)
/F 4
/H /I
/Rect [232.569 231.897 233.565 243.354]
/Subtype /Link
/Type /Annot
>>
endobj
22 0 obj
<<
/AP <<
/N 71 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.fidler2003pathogenesis)
/F 4
/H /I
/Rect [238.365 231.897 259.269 243.354]
/Subtype /Link
/Type /Annot
>>
endobj
23 0 obj
<<
/AP <<
/N 72 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.lambert2017emerging)
/F 4
/H /I
/Rect [87.39 219.441 88.386 230.898]
/Subtype /Link
/Type /Annot
>>
endobj
24 0 obj
<<
/AP <<
/N 73 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.lambert2017emerging)
/F 4
/H /I
/Rect [93.204 219.441 114.108 230.898]
/Subtype /Link
/Type /Annot
>>
endobj
25 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1007/s10237-018-1036-5)
>>
/AP <<
/N 74 0 R
>>
/Border [0 0 0]
/C [0 1 1]
/F 4
/H /I
/Rect [52.857 168.816 203.88 178.422]
/Subtype /Link
/Type /Annot
>>
endobj
26 0 obj
<<
/AP <<
/N 75 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.lambert2017emerging)
/F 4
/H /I
/Rect [363.402 294.159 364.398 305.616]
/Subtype /Link
/Type /Annot
>>
endobj
27 0 obj
<<
/AP <<
/N 76 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.lambert2017emerging)
/F 4
/H /I
/Rect [365.553 294.159 386.457 305.616]
/Subtype /Link
/Type /Annot
>>
endobj
28 0 obj
<<
/AP <<
/N 77 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.seyfried2013origin)
/F 4
/H /I
/Rect [491.913 294.159 492.909 305.616]
/Subtype /Link
/Type /Annot
>>
endobj
29 0 obj
<<
/AP <<
/N 78 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.seyfried2013origin)
/F 4
/H /I
/Rect [494.082 294.159 514.986 305.616]
/Subtype /Link
/Type /Annot
>>
endobj
30 0 obj
<<
/AP <<
/N 79 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.gupta2006cancer)
/F 4
/H /I
/Rect [363.699 281.712 364.695 293.169]
/Subtype /Link
/Type /Annot
>>
endobj
31 0 obj
<<
/AP <<
/N 80 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.gupta2006cancer)
/F 4
/H /I
/Rect [368.046 281.712 388.95 293.169]
/Subtype /Link
/Type /Annot
>>
endobj
32 0 obj
<<
/AP <<
/N 81 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.pavnkova2010molecular)
/F 4
/H /I
/Rect [326.259 231.897 327.255 243.354]
/Subtype /Link
/Type /Annot
>>
endobj
33 0 obj
<<
/AP <<
/N 82 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.pavnkova2010molecular)
/F 4
/H /I
/Rect [330.48 231.897 351.384 243.354]
/Subtype /Link
/Type /Annot
>>
endobj
34 0 obj
<<
/AP <<
/N 83 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.sahai2003differing)
/F 4
/H /I
/Rect [437.778 231.897 438.774 243.354]
/Subtype /Link
/Type /Annot
>>
endobj
35 0 obj
<<
/AP <<
/N 84 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.sahai2003differing)
/F 4
/H /I
/Rect [442.008 231.897 462.912 243.354]
/Subtype /Link
/Type /Annot
>>
endobj
36 0 obj
<<
/AP <<
/N 85 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.pinner2008imaging)
/F 4
/H /I
/Rect [344.331 219.441 345.327 230.898]
/Subtype /Link
/Type /Annot
>>
endobj
37 0 obj
<<
/AP <<
/N 86 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.pinner2008imaging)
/F 4
/H /I
/Rect [350.334 219.441 371.238 230.898]
/Subtype /Link
/Type /Annot
>>
endobj
38 0 obj
<<
/AP <<
/N 87 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.wolf2003compensation)
/F 4
/H /I
/Rect [386.154 157.179 387.15 168.636]
/Subtype /Link
/Type /Annot
>>
endobj
39 0 obj
<<
/AP <<
/N 88 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.wolf2003compensation)
/F 4
/H /I
/Rect [388.791 157.179 409.695 168.636]
/Subtype /Link
/Type /Annot
>>
endobj
40 0 obj
<<
/AP <<
/N 89 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.wyckoff2006rock)
/F 4
/H /I
/Rect [470.619 157.179 471.615 168.636]
/Subtype /Link
/Type /Annot
>>
endobj
41 0 obj
<<
/AP <<
/N 90 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.wyckoff2006rock)
/F 4
/H /I
/Rect [473.265 157.179 494.169 168.636]
/Subtype /Link
/Type /Annot
>>
endobj
42 0 obj
<<
/AP <<
/N 91 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.kalebic1983basement)
/F 4
/H /I
/Rect [471.861 82.452 472.857 93.909]
/Subtype /Link
/Type /Annot
>>
endobj
43 0 obj
<<
/AP <<
/N 92 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.kalebic1983basement)
/F 4
/H /I
/Rect [474.903 82.452 495.807 93.909]
/Subtype /Link
/Type /Annot
>>
endobj
44 0 obj
<<
/AP <<
/N 93 0 R
>>
/Border [0 0 0]
/C [0 1 0]
/Dest (cite.wolf2013physical)
/F 4
/H /I
/Rect [543.267 82.452 544.263 93.909]
/Subtype /Link
/Type /Annot
>>
endobj
45 0 obj
<<
/Length 16659
/Filter /FlateDecode
>>
stream
Hn$E$tvZΌlذ "CC3-#^jr$fUTfFDqc;?|x~x~>op|[br?57Z7w?~Usu0X36֚ou(88ke7{~w;|={}r{;.d'ѥ!LL6dBj&(:|sK
[BbR5O͵{V:"ҚO+A4$sd@NQnyλ_u'`ɹHsZMNBO"Pj6j
`\$q)ȗyZ\َ碛uɧՁz.hgv
+dCrϩմJ
j}6/Ah#ZQ$Lj2A/sITYw>W
Hqغ:piZ:&OeTIJ"O8RM-˺x
tSDOz#ٯ@ M))$DS
d7^caw˃=19]8[# va(X3w' n.LܓJH% n/ՆKqG/ߐO%SNY&윕Q]^>iLXPͺ%rkoZZ.2v(C