%PDF-1.4
%
1 0 obj
<<
/PageLabels 2 0 R
/OpenAction [3 0 R /FitV 910]
/Names 4 0 R
/Type /Catalog
/Outlines 5 0 R
/AcroForm 6 0 R
/OutputIntents [7 0 R 8 0 R]
/Metadata 9 0 R
/Lang (EN)
/PageLayout /SinglePage
/PageMode /UseOutlines
/Pages 10 0 R
>>
endobj
11 0 obj
<<
/Producer <6954657874AE20352E332E3520A9323030302D32303132203154335854204256424120284147504C2D76657273696F6E29>
/Creator (Springer)
/Title (A meta-analysis of genome-wide association studies identifies multiple longevity genes)
/CrossMarkDomains#5B2#5D (springerlink.com)
/Keywords ()
/CrossMarkDomains#5B1#5D (springer.com)
/ModDate (D:20190808174913+02'00')
/Subject (Nature Communications, doi:10.1038/s41467-019-11558-2)
/doi (10.1038/s41467-019-11558-2)
/Author (Joris Deelen)
/CreationDate (D:20190808134859+05'30')
>>
endobj
2 0 obj
<<
/Nums [0 12 0 R]
>>
endobj
3 0 obj
<<
/CropBox [0.0 0.0 595.276 782.362]
/Parent 13 0 R
/Type /Page
/Contents [14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R]
/Resources 22 0 R
/Thumb 23 0 R
/MediaBox [0.0 0.0 595.276 782.362]
/Annots [24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R
34 0 R]
/Rotate 0
>>
endobj
4 0 obj
<<
/Dests 35 0 R
/EmbeddedFiles 36 0 R
>>
endobj
5 0 obj
<<
/Type /Outlines
/Count 27
/Last 37 0 R
/First 37 0 R
>>
endobj
6 0 obj
<<
/Fields []
/DR <<
/Encoding <<
/PDFDocEncoding 38 0 R
>>
/Font <<
/Helv 39 0 R
/ZaDb 40 0 R
>>
>>
/DA (/Helv 0 Tf 0 g )
>>
endobj
7 0 obj
<<
/Type /OutputIntent
/OutputCondition (sRGB)
/DestOutputProfile 41 0 R
/S /GTS_PDFA1
/OutputConditionIdentifier (Custom)
/RegistryName ()
/Info (sRGB IEC61966-2.1)
/SpectralData <<
>>
>>
endobj
8 0 obj
<<
/Type /OutputIntent
/OutputCondition (sRGB)
/DestOutputProfile 41 0 R
/S /ISO_PDFE1
/OutputConditionIdentifier (Custom)
/RegistryName ()
/Info (sRGB IEC61966-2.1)
/SpectralData <<
>>
>>
endobj
9 0 obj
<<
/Length 36929
/Type /Metadata
/Subtype /XML
>>
stream
application/pdf
doi:10.1038/s41467-019-11558-2
A meta-analysis of genome-wide association studies identifies multiple longevity genes
Joris Deelen
Daniel S. Evans
Dan E. Arking
Niccolò Tesi
Marianne Nygaard
Xiaomin Liu
Mary K. Wojczynski
Mary L. Biggs
Ashley van der Spek
Gil Atzmon
Erin B. Ware
Chloé Sarnowski
Albert V. Smith
Ilkka Seppälä
Heather J. Cordell
Janina Dose
Najaf Amin
Alice M. Arnold
Kristin L. Ayers
Nir Barzilai
Elizabeth J. Becker
Marian Beekman
Hélène Blanché
Kaare Christensen
Lene Christiansen
Joanna C. Collerton
Sarah Cubaynes
Steven R. Cummings
Karen Davies
Birgit Debrabant
Jean-François Deleuze
Rachel Duncan
Jessica D. Faul
Claudio Franceschi
Pilar Galan
Vilmundur Gudnason
Tamara B. Harris
Martijn Huisman
Mikko A. Hurme
Carol Jagger
Iris Jansen
Marja Jylhä
Mika Kähönen
David Karasik
Sharon L. R. Kardia
Andrew Kingston
Thomas B. L. Kirkwood
Lenore J. Launer
Terho Lehtimäki
Wolfgang Lieb
Leo-Pekka Lyytikäinen
Carmen Martin-Ruiz
Junxia Min
Almut Nebel
Anne B. Newman
Chao Nie
Ellen A. Nohr
Eric S. Orwoll
Thomas T. Perls
Michael A. Province
Bruce M. Psaty
Olli T. Raitakari
Marcel J. T. Reinders
Jean-Marie Robine
Jerome I. Rotter
Paola Sebastiani
Jennifer Smith
Thorkild I. A. Sørensen
Kent D. Taylor
André G. Uitterlinden
Wiesje van der Flier
Sven J. van der Lee
Cornelia M. van Duijn
Diana van Heemst
James W. Vaupel
David Weir
Kenny Ye
Yi Zeng
Wanlin Zheng
Henne Holstege
Douglas P. Kiel
Kathryn L. Lunetta
P. Eline Slagboom
Joanne M. Murabito
Springer US
Nature Communications, doi:10.1038/s41467-019-11558-2
10.1038/s41467-019-11558-2
http://dx.doi.org/10.1038/s41467-019-11558-2
journal
Nature Communications
© 2019, The Author(s)
2041-1723
10.1038/s41467-019-11558-2
springer.com
springerlink.com
2010-04-23
True
10.1038/s41467-019-11558-2
springer.com
springerlink.com
Springer
2019-08-08T17:49:13+02:00
2019-08-08T13:48:59+05:30
2019-08-08T17:49:13+02:00
True
iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
VoR
uuid:4db04f6b-a277-4bb6-b76a-361d01da0ca0
uuid:08a9eef1-9cab-447b-9eeb-0132c38f8ac8
default
1
converted
uuid:69ce2cdd-b037-48f3-82fd-c0a72d7515e4
converted to PDF/A-2b
pdfToolbox
2019-08-08T13:49:52+05:30
2
B
Joris Deelen
http://orcid.org/0000-0003-4483-3701
Niccolò Tesi
http://orcid.org/0000-0002-1413-5091
Marianne Nygaard
http://orcid.org/0000-0003-0703-2665
Xiaomin Liu
http://orcid.org/0000-0003-2155-3627
Ashley van der Spek
http://orcid.org/0000-0001-7136-0159
Erin B. Ware
http://orcid.org/0000-0003-4731-8158
Ilkka Seppälä
http://orcid.org/0000-0002-5595-2573
Heather J. Cordell
http://orcid.org/0000-0002-1879-5572
Marian Beekman
http://orcid.org/0000-0003-0585-6206
Hélène Blanché
http://orcid.org/0000-0003-2115-575X
Kaare Christensen
http://orcid.org/0000-0002-5429-5292
Pilar Galan
http://orcid.org/0000-0003-1706-3107
Vilmundur Gudnason
http://orcid.org/0000-0001-5696-0084
Carol Jagger
http://orcid.org/0000-0002-6377-9926
David Karasik
http://orcid.org/0000-0002-8826-0530
Carmen Martin-Ruiz
http://orcid.org/0000-0002-3361-6974
Anne B. Newman
http://orcid.org/0000-0002-0106-1150
Eric S. Orwoll
http://orcid.org/0000-0002-8520-7355
Marcel J. T. Reinders
http://orcid.org/0000-0002-1148-1562
Jean-Marie Robine
http://orcid.org/0000-0002-4111-6195
Jerome I. Rotter
http://orcid.org/0000-0001-7191-1723
Jennifer Smith
http://orcid.org/0000-0002-3575-5468
Thorkild I. A. Sørensen
http://orcid.org/0000-0003-4821-430X
Kent D. Taylor
http://orcid.org/0000-0002-2756-4370
André G. Uitterlinden
http://orcid.org/0000-0002-7276-3387
Sven J. van der Lee
http://orcid.org/0000-0003-1606-8643
David Weir
http://orcid.org/0000-0002-1661-2402
Kenny Ye
http://orcid.org/0000-0002-1466-855X
Douglas P. Kiel
http://orcid.org/0000-0001-8474-0310
Kathryn L. Lunetta
http://orcid.org/0000-0002-9268-810X
http://ns.adobe.com/pdf/1.3/
pdf
Adobe PDF Schema
internal
A name object indicating whether the document has been modified to include trapping information
Trapped
Text
http://ns.adobe.com/pdfx/1.3/
pdfx
pdfx
internal
ID of PDF/X standard
GTS_PDFXVersion
Text
internal
Conformance level of PDF/X standard
GTS_PDFXConformance
Text
internal
Company creating the PDF
Company
Text
internal
Date when document was last modified
SourceModified
Text
external
Mirrors crossmark:CrosMarkDomains
CrossMarkDomains
Seq Text
internal
Mirrors crossmark:DOI
doi
Text
http://ns.adobe.com/xap/1.0/mm/
xmpMM
XMP Media Management Schema
internal
UUID based identifier for specific incarnation of a document
InstanceID
URI
internal
The common identifier for all versions and renditions of a document.
OriginalDocumentID
URI
http://www.aiim.org/pdfa/ns/id/
pdfaid
PDF/A ID Schema
internal
Part of PDF/A standard
part
Integer
internal
Amendment of PDF/A standard
amd
Text
internal
Conformance level of PDF/A standard
conformance
Text
http://crossref.org/crossmark/1.0/
crossmark
crossmark
internal
CrossMarkDomains
CrossMarkDomains
Seq Text
internal
CrossmarkDomainExclusive
CrossmarkDomainExclusive
Text
internal
Usual same as prism:doi
DOI
Text
external
The date when a publication was published.
MajorVersionDate
Text
http://prismstandard.org/namespaces/basic/2.0/
prism
Prism
external
The aggregation type specifies the unit of aggregation for a content collection.
Comment
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element.
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary.
aggregationType
Text
external
Copyright
copyright
Text
external
The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only.
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL).
doi
Text
external
ISSN for an electronic version of the issue in which the resource occurs.
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn.
issn
Text
external
Title of the magazine, or other publication, in which a resource was/will be published.
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date.
Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”
publicationName
Text
external
This element provides the url for an article or unit of content.
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element.
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.
url
Text
http://springernature.com/ns/xmpExtensions/2.0/
sn
Springer Nature ORCID Schema
external
Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.
authorInfo
Bag AuthorInformation
Specifies the types of author information: name and ORCID of an author.
http://springernature.com/ns/xmpExtensions/2.0/authorInfo/
author
AuthorInformation
Gives the name of an author.
name
Text
Gives the ORCID of an author.
orcid
URI
http://www.niso.org/schemas/jav/1.0/
jav
NISO
external
Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record
journal_article_version
Closed Choice of Text
endstream
endobj
10 0 obj
<<
/Type /Pages
/Count 15
/Kids [13 0 R 42 0 R]
>>
endobj
12 0 obj
<<
/S /D
>>
endobj
13 0 obj
<<
/Parent 10 0 R
/Type /Pages
/Count 11
/Kids [43 0 R 3 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R
52 0 R]
>>
endobj
14 0 obj
<<
/Length 1560
/Filter /FlateDecode
>>
stream
H|WIoFFz
s4rtl'i ]@KĂfm1p{$(my/EU7K]a? є
RR崥̨TÂj6=|ldm~a7 (1cXZƨ@o*`@fٱ싼8KWu%pGy
k@l_c_]fR,VE_5?߀m{/