Research output per year
Research output per year
- 35 results
Search results
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A modular versatile chip carrier for high-throughput screening of cell-biomaterial interactions
Unadkat, HV., Rewagad, RR., Hulsman, M., Hulshof, GFB., Truckenmüller, RK., Stamatialis, DF., Reinders, MJT., Eijkel, JCT., van den Berg, A., Blitterswijk, CA. & de Boer, J., 2013, In: Journal of the Royal Society Interface. 10, 78, p. 1-7 7 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access6 Citations (Scopus) -
An algorithm-based topographical biomaterials library to instruct cell fate
Unadkat, HV., Hulsman, M., Cornelissen, K., Papenburg, BJ., Truckenmüller, RK., Post, GF., Uetz, M., Reinders, MJT., Stamatialis, D., Blitterswijk, CA. & de Boer, J., 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 40, p. 16565-16570 6 p.Research output: Contribution to journal › Article › Scientific › peer-review
330 Citations (Scopus) -
Analysis of high-throughput screening reveals the effect of surface topographies on cellular morphology
Hulsman, M., Hulshof, F., Unadkat, H., Papenburg, BJ., Stamatialis, DF., Truckenmüller, R., van Blitterswijk, C., de Boer, J. & Reinders, MJT., 2015, In: Acta Biomaterialia. 15, March, p. 29-38 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access58 Citations (Scopus) -
A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity
van der Lee, S., Conway, O. J., Hansen, I., Carrasquillo, M. M., Kleineidam, L., van den Akker, E., Hulsman, M., Tesi, N., Reinders, M. J. T. & More Authors, 2019, In: Acta Neuropathologica. 138, 2, p. 237-250 14 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile67 Citations (Scopus)85 Downloads (Pure) -
A rare genetic variant in the PLCG2 gene is associated with a reduced risk of all major types of dementia and an increased risk to reach an extremely old age
van der Lee, S. J., Jansen, I. E., Pletnikova, O., Blauwendraat, C., Hulsman, M., Dalmasso, M. C., Kawalia, A., Ramirez, A., van der Flier, W. M., Scheltens, P., Reinders, M. & More Authors, 2018, In: Alzheimer's & Dementia. 14, 7, p. 1648-1649 2 p.Research output: Contribution to journal › Article › Scientific › peer-review
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Centenarian controls increase variant effect sizes by an average twofold in an extreme case–extreme control analysis of Alzheimer’s disease
Tesi, N., van der Lee, S. J., Hulsman, M., Jansen, I. E., Stringa, N., van Schoor, N., Meijers-Heijboer, H., Reinders, M. J. T., Holstege, H. & More Authors, 2019, In: European Journal of Human Genetics. 27, 2, p. 244-253 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile38 Citations (Scopus)100 Downloads (Pure) -
Characterization of pathogenic SORL1 genetic variants for association with Alzheimer's disease: A clinical interpretation strategy
Holstege, H., van Der Lee, S. J., Hulsman, M., Hang Wong, T., van Rooij, J. G. J., Weiss, M., Louwersheimer, E., Wolters, F. J., Amin, N., Reinders, M. J. T. & More Authors, 2017, In: European Journal of Human Genetics. 25, 8, p. 973-981 9 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile77 Citations (Scopus)59 Downloads (Pure) -
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
Tesi, N., Stringa, N., Hadjigeorgiou, G., Hulsman, M., van Schoor, N. M., Ruiz, A., Jansen, I. E., Holstege, H., van der Lee, S. J. & More Authors, 2021, In: Nature Communications. 12, 1, 16 p., 3417.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile91 Citations (Scopus)34 Downloads (Pure) -
Detecting recurrent gene mutation in interaction network context using multi-scale graph diffusion
Babaei, S., Hulsman, M., Reinders, MJT. & de Ridder, J., 2013, In: BMC Bioinformatics. 14:29, p. 1-12 12 p.Research output: Contribution to journal › Article › Scientific › peer-review
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EIF2AK3 variants in Dutch patients with Alzheimer's disease
Wong, T. H., van der Lee, S. J., van Rooij, J. G. J., Meeter, L. H. H., Frick, P., Melhem, S., Seelaar, H., Ikram, M. A., Holstege, H., Hulsman, M. & More Authors, 2019, In: Neurobiology of Aging. 73, p. 229.e11-229.e18Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile8 Citations (Scopus)96 Downloads (Pure) -
Evolutionary optimization of kernel weights improves protein complex comebership prediction
Hulsman, M., Reinders, MJT. & de Ridder, D., 2009, In: IEEE - ACM Transactions on Computational Biology and Bioinformatics. 6, 3, p. 427-437 11 p.Research output: Contribution to journal › Article › Scientific › peer-review
9 Citations (Scopus) -
Exploring sequence characteristics related to high-level production of secreted proteins in Aspergillus niger
van den Berg, BA., Reinders, MJT., Hulsman, M., Wu, L., Pel, HJ., Roubos, JA. & de Ridder, D., 2012, In: PLoS ONE. 7, 10, p. 1-11 11 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access18 Citations (Scopus) -
FluG affects secretion in colonies of Aspergillus niger
Wang, F., Krijgsheld, P., Hulsman, M., De Bekker, C., Müller, WH., Reinders, MJT., de Vries, RP. & Wösten, HAB., 2014, In: Antonie van Leeuwenhoek: international journal of general and molecular microbiology. 107, 1, p. 1-16 16 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access12 Citations (Scopus) -
Hi-C chromatin interaction networks predict co-expression in the mouse cortex
Babaei, S., Mahfouz, AMETA., Hulsman, M., Lelieveldt, BPF., de Ridder, J. & Reinders, MJT., 2015, In: PLoS Computational Biology (Print). 11, 5, p. 1-21 21 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access37 Citations (Scopus) -
Immune response and endocytosis pathways are associated with the resilience against Alzheimer’s disease
Tesi, N., van der Lee, S. J., Hulsman, M., Jansen, I. E., Stringa, N., van Schoor, N., Scheltens, P., van der Flier, W. M., Huisman, M., Reinders, M. J. T. & Holstege, H., 2020, In: Translational Psychiatry. 10, 1, p. 1-12 12 p., 332.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile27 Citations (Scopus)27 Downloads (Pure) -
Improved intra-array and interarray normalization of peptide microarray phosphorylation for phosphorylome and kinome profiling by rational selection of relevant spots
Scholma, J., Fuhler, G., Joore, J., Hulsman, M., Schivo, S., List, A. F., Reinders, M., Peppelenbosch, M. & Post, J. N., 26 May 2016, In: Scientific Reports. p. 1-13 13 p., 26695.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile5 Citations (Scopus)41 Downloads (Pure) -
Mapping the genetic landscape of early-onset Alzheimer’s disease in a cohort of 36 families
Netherlands Brain Bank, 2022, In: Alzheimer's Research and Therapy. 14, 1, 14 p., 77.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile3 Citations (Scopus)40 Downloads (Pure) -
Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging
van den Akker, EB., Passtoors, WM., Jansen, R., van Zwet, EW., Goeman, JJ., Hulsman, M., Emilsson, V., Perola, M., Wilemsen, G., Penninx, BWJH., Heijmans, BT., Maier, A. B., Boomsma, DI., Kok, JN., Slagboom, PE., Reinders, MJT. & Beekman, M., 2014, In: Aging Cell. 13, 2, p. 216-225 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access37 Citations (Scopus) -
Mining for osteogenic surface topographies: In silico design to in vivo osseo-integration
Hulshof, F. F. B., Papenburg, B. J., Vasilevich, A., Hulsman, M., Zhao, Y., Levers, M., Fekete, N., de Boer, M., Yuan, H., Reinders, M. & More Authors, 2017, In: Biomaterials. 137, p. 49-60 12 p.Research output: Contribution to journal › Article › Scientific › peer-review
57 Citations (Scopus) -
Molecular mechanisms of biomaterial-driven osteogenic differentiation in human mesenchymal stromal cells
Barradas, AM., Monticone, V., Hulsman, M., Danoux, C., Fernandes, H., Tahmaseni Birgani, Z., Barrère-de Groot, F., Yuan, H., Reinders, MJT., Habibovic, P., van Blitterswijk, C. & de Boer, J., 2013, In: Integrative Biology: quantitative biosciences from nano to macro. 5, 7, p. 920-931 12 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access92 Citations (Scopus) -
New insights into the genetic etiology of Alzheimer’s disease and related dementias
van der Lee, S. J., De Rojas, I., Holstege, H., Hulsman, M., Reinders, M. J. T., Tesi, N., van Rooij, J., Zhao, Y., Zhang, X. & More Authors, 2022, In: Nature Genetics. 54, 4, p. 412-436 25 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile348 Citations (Scopus)62 Downloads (Pure) -
Pathway-specific polygenic risk score of AD-associated genetic variants associated with AD risk, resilience against AD, and progression to AD
Tesi, N., Van Der Lee, S. J., Hulsman, M., Jansen, I. E., Stringa, N., van Schoor, N., Huisman, M., Scheltens, P., Reinders, M. J., van der Flier, W. M. & Holstege, H., 2021, In: Alzheimer's & dementia : the journal of the Alzheimer's Association. 17, p. e053500 1 p.Research output: Contribution to journal › Article › Scientific › peer-review
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Polygenic Risk Score of Longevity Predicts Longer Survival across an Age Continuum
Tesi, N., Van Der Lee, S. J., Hulsman, M., Jansen, I. E., Stringa, N., Van Schoor, N. M., Huisman, M., Reinders, M. J. T., Holstege, H. & More Authors, 2021, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 76, 5, p. 750-759 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile15 Citations (Scopus)48 Downloads (Pure) -
Predicting the therapeutic efficacy of MSC in bone tissue engineering using the molecular marker CADM1
Mentink, A., Hulsman, M., Groen, N., Licht, R., Dechering, KJ., Stok, J., Alves, HA., Dhert, WJ., van Someren, EP., Reinders, MJT., Blitterswijk, CA. & de Boer, J., 2013, In: Biomaterials. 34, 19, p. 4591-4601 11 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access45 Citations (Scopus) -
Resilience and resistance to the accumulation of amyloid plaques and neurofibrillary tangles in centenarians: An age-continuous perspective
Zhang, M., Ganz, A. B., Rohde, S., Rozemuller, A. J. M., Bank, N. B., Reinders, M. J. T., Scheltens, P., Hulsman, M., Hoozemans, J. J. M. & Holstege, H., 2022, In: Alzheimer's and Dementia. 19, 7, p. 2831-2841 11 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile6 Citations (Scopus)86 Downloads (Pure) -
Scalable multi whole-genome alignment using recursive exact matching
Linthorst, J., Hulsman, M., Holstege, H. & Reinders, MJT., 2015, In: bioRxiv. 2015, p. 1-17 17 p.Research output: Contribution to journal › Article › Professional
Open Access -
Scale-space measures for graph topology link protein network architecture to function
Hulsman, M., Dimitrakopoulos, C. & de Ridder, J., 2014, In: Bioinformatics. 30, 12, p. 1237-1245 9 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access10 Citations (Scopus) -
SnpXplorer: A web application to explore human SNP-associations and annotate SNP-sets
Tesi, N., Van Der Lee, S., Hulsman, M., Holstege, H. & Reinders, M. J. T., 2021, In: Nucleic Acids Research. 49, W1, p. W603-W612 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile8 Citations (Scopus)33 Downloads (Pure) -
Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis
Holstege, H., Pfeiffer, W., Sie, D., Hulsman, M., Nicholas, TJ., Lee, CC., Ross, T., Lin, J., Miller, MA., Ylstra, B., Meijers-Heijboer, H., Brugman, MH., Staal, FJT., Holstege, G., Reinders, MJT., Harkins, TT., levy, S. & Sistermans, EA., 2014, In: Genome Research. 24, 5, p. 733-742 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access110 Citations (Scopus) -
Switching from a unicellular to multicellular organization in an Aspergillus niger hypha
Bleichrodt, RJ., Hulsman, M., Wösten, HAB. & Reinders, MJT., 2015, In: mBio (online). 6, 2, p. 1-10 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access23 Citations (Scopus) -
The correlation between neuropathology levels and cognitive performance in centenarians
Zhang, M., Ganz, A. B., Rohde, S., Lorenz, L., Rozemuller, A. J. M., Reinders, M. J. T., Hulsman, M., Hoozemans, J. J. M., Holstege, H. & More Authors, 2023, In: Alzheimer's and Dementia. 19, 11, p. 5036-5047 12 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile3 Citations (Scopus)74 Downloads (Pure) -
The Effect of Alzheimer’s Disease-Associated Genetic Variants on Longevity
Tesi, N., Hulsman, M., van der Lee, S. J., Jansen, I. E., Stringa, N., van Schoor, N. M., Scheltens, P., Reinders, M. J. T., Holstege, H. & More Authors, 2021, In: Frontiers in Genetics. 12, 12 p., 748781.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile5 Citations (Scopus)26 Downloads (Pure) -
The majority of the patients with a monogenic predisposition for dementia did not fulfill current criteria for genetic testing
Van Der Lee, S. J., Hulsman, M., van Spaendonk, R. M. L., Cohn-Hokke, P. E., van der Flier, W. M., Holstege, H. & Scheltens, P., 2021, In: Alzheimer's & dementia : the journal of the Alzheimer's Association. 17, p. e052075Research output: Contribution to journal › Article › Scientific › peer-review
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Transcriptomic and molecular genetic analysis of the cell wall salvage response of Aspergillus niger to the absence of galactofuranose synthesis
Park, J., Hulsman, M., Arentshorst, M., Breeman, M., Alazi, E., Lagendijk, E. L., Rocha, M. C., Malavazi, I., Nitsche, B. M., van den Hondel, C. A. M. J. J., Meyer, V. & Ram, A. F. J., 2016, In: Cellular Microbiology. 18, 9, p. 1268-1284 17 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile25 Citations (Scopus)43 Downloads (Pure) -
Unbiased quantitative models of protein translation derived from ribosome profiling data
Gritsenko, A., Hulsman, M., Reinders, MJT. & de Ridder, D., 2015, In: PLoS Computational Biology (Print). 11, 8, p. 1-26 26 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access19 Citations (Scopus)