Analysis of attenuation coefficient estimation in Fourier-domain OCT of semi-infinite media

Babak Ghafaryasl; Koenraad A. Vermeer; Jeroen Kalkman; Tom Callewaert; Johannes F.D.E. Boer; Lucas J. van Vliet

doi:10.1364/BOE.403283

Analysis of attenuation coefficient estimation in Fourier-domain OCT of semi-infinite media

Babak Ghafaryasl^*, Koenraad A. Vermeer, Jeroen Kalkman, Tom Callewaert, Johannes F.D.E. Boer, Lucas J. van Vliet

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

The attenuation coefficient (AC) is an optical property of tissue that can be estimated from optical coherence tomography (OCT) data. In this paper, we aim to estimate the AC accurately by compensating for the shape of the focused beam. For this, we propose a method to estimate the axial PSF model parameters and AC by fitting a model for an OCT signal in a homogenous sample to the recorded OCT signal. In addition, we employ numerical analysis to obtain the theoretical optimal precision of the estimated parameters for different experimental setups. Finally, the method is applied to OCT B-scans obtained from homogeneous samples. The numerical and experimental results show accurate estimations of the AC and the focus location when the focus is located inside the sample.

Original language	English
Pages (from-to)	6093-6107
Journal	Biomedical Optics Express
Volume	11
Issue number	11
DOIs	https://doi.org/10.1364/BOE.403283
Publication status	Published - 2020

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title = "Analysis of attenuation coefficient estimation in Fourier-domain OCT of semi-infinite media",

abstract = "The attenuation coefficient (AC) is an optical property of tissue that can be estimated from optical coherence tomography (OCT) data. In this paper, we aim to estimate the AC accurately by compensating for the shape of the focused beam. For this, we propose a method to estimate the axial PSF model parameters and AC by fitting a model for an OCT signal in a homogenous sample to the recorded OCT signal. In addition, we employ numerical analysis to obtain the theoretical optimal precision of the estimated parameters for different experimental setups. Finally, the method is applied to OCT B-scans obtained from homogeneous samples. The numerical and experimental results show accurate estimations of the AC and the focus location when the focus is located inside the sample.",

author = "Babak Ghafaryasl and Vermeer, {Koenraad A.} and Jeroen Kalkman and Tom Callewaert and Boer, {Johannes F.D.E.} and {van Vliet}, {Lucas J.}",

year = "2020",

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volume = "11",

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T1 - Analysis of attenuation coefficient estimation in Fourier-domain OCT of semi-infinite media

AU - Ghafaryasl, Babak

AU - Vermeer, Koenraad A.

AU - Kalkman, Jeroen

AU - Callewaert, Tom

AU - Boer, Johannes F.D.E.

AU - van Vliet, Lucas J.

PY - 2020

Y1 - 2020

N2 - The attenuation coefficient (AC) is an optical property of tissue that can be estimated from optical coherence tomography (OCT) data. In this paper, we aim to estimate the AC accurately by compensating for the shape of the focused beam. For this, we propose a method to estimate the axial PSF model parameters and AC by fitting a model for an OCT signal in a homogenous sample to the recorded OCT signal. In addition, we employ numerical analysis to obtain the theoretical optimal precision of the estimated parameters for different experimental setups. Finally, the method is applied to OCT B-scans obtained from homogeneous samples. The numerical and experimental results show accurate estimations of the AC and the focus location when the focus is located inside the sample.

AB - The attenuation coefficient (AC) is an optical property of tissue that can be estimated from optical coherence tomography (OCT) data. In this paper, we aim to estimate the AC accurately by compensating for the shape of the focused beam. For this, we propose a method to estimate the axial PSF model parameters and AC by fitting a model for an OCT signal in a homogenous sample to the recorded OCT signal. In addition, we employ numerical analysis to obtain the theoretical optimal precision of the estimated parameters for different experimental setups. Finally, the method is applied to OCT B-scans obtained from homogeneous samples. The numerical and experimental results show accurate estimations of the AC and the focus location when the focus is located inside the sample.

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DO - 10.1364/BOE.403283

M3 - Article

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SN - 2156-7085

VL - 11

SP - 6093

EP - 6107

JO - Biomedical Optics Express

JF - Biomedical Optics Express

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ER -

Analysis of attenuation coefficient estimation in Fourier-domain OCT of semi-infinite media

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