2D Representation of Transcriptomes by t-SNE Exposes Relatedness between Human Tissues

E Taskesen, MJT Reinders

Research output: Contribution to journalArticleScientificpeer-review

18 Citations (Scopus)

Abstract

The GTEx Consortium reported that hierarchical clustering of RNA profiles from 25 unique tissue types among 1641 individuals accurately distinguished the tissue types, but a multidimensional scaling failed to generate a 2D projection of the data that separates tissue-subtypes. In this study we show that a projection by t-Distributed Stochastic Neighbor Embedding is in line with the cluster analysis which allows a more detailed examination and visualization of human tissue relationships.
Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalPLoS ONE
Volume11
Issue number2
DOIs
Publication statusPublished - 23 Feb 2016

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