TY - JOUR
T1 - 3D printed titanium scaffolds with ordered TiO2 nanotubular surface and mesoporous bioactive glass for bone repair
AU - Zhao, Pengyu
AU - Liu, Yaqin
AU - Li, Tian
AU - Zhou, Yanling
AU - Leeflang, Sander
AU - Chen, Lei
AU - Wu, Chengtie
AU - Zhou, Jie
AU - Huan, Zhiguang
PY - 2020
Y1 - 2020
N2 - Titanium alloy scaffolds have recently gained substantial interest for the treatment of critical-size bone defect, particularly along with the maturity of the 3D printing technology that is capable of turning scaffold design ideas into real implants. As titanium alloys lack surface osteogenic activity, for improved biological performance of such scaffolds, surface modification is necessary. Various coating materials and coating methods have been explored. In this study, we developed a unique surface modification method to provide the surface of 3D printed titanium scaffolds with nano-sized structure and bioactive agent. Uniform, ordered TiO2 nanotube arrays were formed by applying two-step anodization, and then mesoporous bioactive glass (MBG) was loaded into nanotubes. The results of in vitro immersion testing showed that bioactive ions, i.e., Si and Ca ions, could be steadily and continuously released from MBG into basal medium. The assessment of the responses of hBMSCs confirmed that the surface-modified scaffolds supported the adhesion and proliferation of hBMSCs, indicating good surface cytocompatibility. The developed method of combining surface nanostructure and bioactive agent could be used as a new strategy to improve the osteogenic activity of 3D printed titanium alloy scaffolds.
AB - Titanium alloy scaffolds have recently gained substantial interest for the treatment of critical-size bone defect, particularly along with the maturity of the 3D printing technology that is capable of turning scaffold design ideas into real implants. As titanium alloys lack surface osteogenic activity, for improved biological performance of such scaffolds, surface modification is necessary. Various coating materials and coating methods have been explored. In this study, we developed a unique surface modification method to provide the surface of 3D printed titanium scaffolds with nano-sized structure and bioactive agent. Uniform, ordered TiO2 nanotube arrays were formed by applying two-step anodization, and then mesoporous bioactive glass (MBG) was loaded into nanotubes. The results of in vitro immersion testing showed that bioactive ions, i.e., Si and Ca ions, could be steadily and continuously released from MBG into basal medium. The assessment of the responses of hBMSCs confirmed that the surface-modified scaffolds supported the adhesion and proliferation of hBMSCs, indicating good surface cytocompatibility. The developed method of combining surface nanostructure and bioactive agent could be used as a new strategy to improve the osteogenic activity of 3D printed titanium alloy scaffolds.
KW - Anodization
KW - Mesoporous bioactive glass
KW - Nanotube
KW - Scaffold
KW - Titanium
UR - http://www.scopus.com/inward/record.url?scp=85091261268&partnerID=8YFLogxK
U2 - 10.1016/j.pnsc.2020.08.009
DO - 10.1016/j.pnsc.2020.08.009
M3 - Article
AN - SCOPUS:85091261268
SN - 1002-0071
VL - 30
SP - 502
EP - 509
JO - Progress in Natural Science: materials international
JF - Progress in Natural Science: materials international
IS - 4
ER -