A rising star: A comprehensive approach to Akkermansia muciniphila ecosystems, interactions and applications

Mark C.M. van Loosdrecht; Sharon Y. Geerlings

A rising star: A comprehensive approach to Akkermansia muciniphila ecosystems, interactions and applications

Mark C.M. van Loosdrecht, Sharon Y. Geerlings^*

^*Corresponding author for this work

BT/Environmental Biotechnology

Research output: Thesis › Dissertation (external)

Abstract

Akkermansia muciniphila is a fascinating intestinal symbiont, which has received considerable attention over the last two decades due to its mechanisms of action to improve host health. The research projects in this thesis aimed to assess the functions of A. muciniphila in the human body and other hosts as well as in in vitro and in vivo models. Therefore, we used bioinformatics and phylogenetic analysis to identify newly isolated Akkermansia strains from the human body and different mammalian hosts. Furthermore, we aimed to study the functions of A. muciniphila in several in vitro and in vivo models to elucidate the stability of these functions in food-grade media, co-cultivations and a synthetic community. Lastly, we gained insight into one of the physiological characteristics of A. muciniphila, namely the production of exopolysaccharides.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Wageningen University & Research
Supervisors/Advisors	van Loosdrecht, Mark C.M., Supervisor Belzer, Clara, Supervisor, External person de Vos, Willem M., Supervisor, External person
Thesis sponsors	Soehngen Institute of Anaerobic Microbiology
Award date	18 Jan 2023
Print ISBNs	9789464475074; 9464475072
Publication status	Published - 18 Jan 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "A rising star: A comprehensive approach to Akkermansia muciniphila ecosystems, interactions and applications",

abstract = "Akkermansia muciniphila is a fascinating intestinal symbiont, which has received considerable attention over the last two decades due to its mechanisms of action to improve host health. The research projects in this thesis aimed to assess the functions of A. muciniphila in the human body and other hosts as well as in in vitro and in vivo models. Therefore, we used bioinformatics and phylogenetic analysis to identify newly isolated Akkermansia strains from the human body and different mammalian hosts. Furthermore, we aimed to study the functions of A. muciniphila in several in vitro and in vivo models to elucidate the stability of these functions in food-grade media, co-cultivations and a synthetic community. Lastly, we gained insight into one of the physiological characteristics of A. muciniphila, namely the production of exopolysaccharides.",

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year = "2023",

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language = "English",

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type = "Dissertation (external)",

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TY - THES

T1 - A rising star: A comprehensive approach to Akkermansia muciniphila ecosystems, interactions and applications

AU - van Loosdrecht, Mark C.M.

AU - Geerlings, Sharon Y.

PY - 2023/1/18

Y1 - 2023/1/18

N2 - Akkermansia muciniphila is a fascinating intestinal symbiont, which has received considerable attention over the last two decades due to its mechanisms of action to improve host health. The research projects in this thesis aimed to assess the functions of A. muciniphila in the human body and other hosts as well as in in vitro and in vivo models. Therefore, we used bioinformatics and phylogenetic analysis to identify newly isolated Akkermansia strains from the human body and different mammalian hosts. Furthermore, we aimed to study the functions of A. muciniphila in several in vitro and in vivo models to elucidate the stability of these functions in food-grade media, co-cultivations and a synthetic community. Lastly, we gained insight into one of the physiological characteristics of A. muciniphila, namely the production of exopolysaccharides.

AB - Akkermansia muciniphila is a fascinating intestinal symbiont, which has received considerable attention over the last two decades due to its mechanisms of action to improve host health. The research projects in this thesis aimed to assess the functions of A. muciniphila in the human body and other hosts as well as in in vitro and in vivo models. Therefore, we used bioinformatics and phylogenetic analysis to identify newly isolated Akkermansia strains from the human body and different mammalian hosts. Furthermore, we aimed to study the functions of A. muciniphila in several in vitro and in vivo models to elucidate the stability of these functions in food-grade media, co-cultivations and a synthetic community. Lastly, we gained insight into one of the physiological characteristics of A. muciniphila, namely the production of exopolysaccharides.

M3 - Dissertation (external)

SN - 9789464475074; 9464475072

ER -

A rising star: A comprehensive approach to Akkermansia muciniphila ecosystems, interactions and applications

Abstract

UN SDGs

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