Adapting Temperature Predictions to MR Imaging in Treatment Position to Improve Simulation-Guided Hyperthermia for Cervical Cancer

Iva Vilasboas-Ribeiro*, Kemal Sumser, Sven Nouwens, Theresa Feddersen, W. P.M.H. Heemels, Gerard C. Van Rhoon, Margarethus M. Paulides*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)
15 Downloads (Pure)

Abstract

Hyperthermia treatment consists of elevating the temperature of the tumor to increase the effectiveness of radiotherapy and chemotherapy. Hyperthermia treatment planning (HTP) is an important tool to optimize treatment quality using pre-treatment temperature predictions. The accuracy of these predictions depends on modeling uncertainties such as tissue properties and positioning. In this study, we evaluated if HTP accuracy improves when the patient is imaged inside the applicator at the start of treatment. Because perfusion is a major uncertainty source, the importance of accurate treatment position and anatomy was evaluated using different perfusion values. Volunteers were scanned using MR imaging without ('planning setup') and with the MR-compatible hyperthermia device ('treatment setup'). Temperature-based quality indicators were used to assess the differences between the standard, apparent and the optimized hyperthermia dose. We conclude that pre-treatment imaging can improve HTP predictions accuracy but also, that tissue perfusion modelling is crucial if temperature-based optimization is applied.

Original languageEnglish
Pages (from-to)99-106
JournalIEEE Open Journal of Engineering in Medicine and Biology
Volume5
DOIs
Publication statusPublished - 2024

Keywords

  • Hyperthermia treatment planning (HTP)
  • MR imaging
  • optimization approach
  • perfusion
  • thermal modeling

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