Adaptive optics plug-and-play setup for high-resolution microscopes with multi-actuator adaptive lens

M. Quintavalla, P. Pozzi, Michel Verhaegen, Hielke Bijlsma, Hans Verstraete, S. Bonora

Research output: Chapter in Book/Conference proceedings/Edited volumeConference contributionScientificpeer-review

1 Citation (Scopus)
29 Downloads (Pure)

Abstract

Adaptive Optics (AO) has revealed as a very promising technique for high-resolution microscopy, where the presence of optical aberrations can easily compromise the image quality. Typical AO systems however, are almost impossible to implement on commercial microscopes. We propose a simple approach by using a Multi-actuator Adaptive Lens (MAL) that can be inserted right after the objective and works in conjunction with an image optimization software allowing for a wavefront sensorless correction. We presented the results obtained on several commercial microscopes among which a confocal microscope, a fluorescence microscope, a light sheet microscope and a multiphoton microscope.

Original languageEnglish
Title of host publicationProceedings of SPIE
Subtitle of host publicationMultiphoton Microscopy in the Biomedical Sciences XVIII
EditorsA. Periasamy, P.T.C. So, K. König, X.S. Xie
Place of PublicationBellingham, WA, USA
PublisherSPIE
Number of pages6
Volume10498
ISBN (Electronic)9781510614819
DOIs
Publication statusPublished - 2018
EventSPIE BiOS: Multiphoton Microscopy in the Biomedical Sciences XVIII 2018 - San Francisco, United States
Duration: 28 Jan 201830 Jan 2018

Publication series

NameProceedings SPIE
Volume10498

Conference

ConferenceSPIE BiOS: Multiphoton Microscopy in the Biomedical Sciences XVIII 2018
CountryUnited States
CitySan Francisco
Period28/01/1830/01/18

Keywords

  • Adaptive lens
  • Adaptive optics
  • High-resolution microscopy
  • optimizaion

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    Quintavalla, M., Pozzi, P., Verhaegen, M., Bijlsma, H., Verstraete, H., & Bonora, S. (2018). Adaptive optics plug-and-play setup for high-resolution microscopes with multi-actuator adaptive lens. In A. Periasamy, P. T. C. So, K. König, & X. S. Xie (Eds.), Proceedings of SPIE: Multiphoton Microscopy in the Biomedical Sciences XVIII (Vol. 10498). [104981X] (Proceedings SPIE; Vol. 10498). SPIE. https://doi.org/10.1117/12.2290036