Advancing single-molecule instrumentation through nanoscale optics, fabrication, and surface functionalization

Seungkyu Ha

Research output: ThesisDissertation (TU Delft)

26 Downloads (Pure)

Abstract

This thesis describes developments in the single-molecule instrumentation, in particular optical torque wrench and DNA nanocurtains, with the goal of employing these techniques in studies of biomolecules and biomotors. Importantly, the use of single-crystal rutile titanium dioxide nanocylinders is suggested for optical torque wrench, enabling access to a larger torque-speed space and improvement in spatiotemporal resolution.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Delft University of Technology
Supervisors/Advisors
  • Dekker, N.H., Supervisor
Award date16 Oct 2018
Print ISBNs978-90-8593-367-0
DOIs
Publication statusPublished - 2018

Keywords

  • biophysics
  • single-molecule
  • nano-optics
  • nanofabrication
  • surface functionalization
  • optical tweezers
  • optical torque wrench
  • DNA nanocurtain
  • fluorescence microscopy

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