An Ultrasonically-Powered System for 1.06mm3 Implantable Optogenetics and Drug Delivery Dust

Kjeld Laursen; Milad Zamani; Yasser Rezaeiyan; Seyedsina Hosseini; Tanmay Mondal; Brian Corbett; Abdel Mouttalib Ouagazzal; Marianne Amalric; Farshad Moradi

doi:10.1109/TCSII.2023.3289028

An Ultrasonically-Powered System for 1.06mm³ Implantable Optogenetics and Drug Delivery Dust

Kjeld Laursen, Milad Zamani, Yasser Rezaeiyan, Seyedsina Hosseini, Tanmay Mondal, Brian Corbett, Abdel Mouttalib Ouagazzal, Marianne Amalric, Farshad Moradi

Bio-Electronics

Research output: Contribution to journal › Article › Scientific › peer-review

1 Citation (Scopus)

24 Downloads (Pure)

Abstract

This brief presents an ultrasonically powered micro-system for deep tissue optogenetic stimulation. The developed system is composed of a Base for Powering and Controlling (BPC) and an implantable Dust for optogenetics and drug delivery. The Dust consists of a piezoelectric crystal, a rectifier chip, and a micro-scale custom-designed light-emitting-diode (μ LED) integrated, miniaturized, and envisioned to be used for freely moving animal studies. The proposed Dust operates in frequencies up to 5 MHz, power levels in the 0-10 mW range, achieves start-up within 1.8~μ s at 2.9 MHz operating frequency at 14.4 mW/mm2 ultrasound power density, and 98.1% chip efficiency at 2 mW input power. With the BPC implemented and attached to ( 500~μ m )3 PZT4 crystals, set to 60 V at 2.8 MHz operating frequency at 3 mm distance in demineralized water, the dust delivered up to 6 mW to its load (μ LED for optogenetics), which translates to 0.11% total system efficiency.

Original language	English
Pages (from-to)	3937-3941
Number of pages	5
Journal	IEEE Transactions on Circuits and Systems II: Express Briefs
Volume	70
Issue number	10
DOIs	https://doi.org/10.1109/TCSII.2023.3289028
Publication status	Published - 2023

Bibliographical note

Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care
Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

Keywords

Bridge circuits
Crystals
Dust
Light emitting diodes
Logic gates
Optogenetic stimulation
Optogenetics
piezoelectric
rectifier
Rectifiers
Substrates
Ultrasonic power transfer

Access to Document

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An_Ultrasonically-Powered_System_for_1.06_mm3_Implantable_Optogenetics_and_Drug_Delivery_DustFinal published version, 5.49 MB

Cite this

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title = "An Ultrasonically-Powered System for 1.06mm3 Implantable Optogenetics and Drug Delivery Dust",

abstract = "This brief presents an ultrasonically powered micro-system for deep tissue optogenetic stimulation. The developed system is composed of a Base for Powering and Controlling (BPC) and an implantable Dust for optogenetics and drug delivery. The Dust consists of a piezoelectric crystal, a rectifier chip, and a micro-scale custom-designed light-emitting-diode (μ LED) integrated, miniaturized, and envisioned to be used for freely moving animal studies. The proposed Dust operates in frequencies up to 5 MHz, power levels in the 0-10 mW range, achieves start-up within 1.8~μ s at 2.9 MHz operating frequency at 14.4 mW/mm2 ultrasound power density, and 98.1% chip efficiency at 2 mW input power. With the BPC implemented and attached to ( 500~μ m )3 PZT4 crystals, set to 60 V at 2.8 MHz operating frequency at 3 mm distance in demineralized water, the dust delivered up to 6 mW to its load (μ LED for optogenetics), which translates to 0.11% total system efficiency.",

keywords = "Bridge circuits, Crystals, Dust, Light emitting diodes, Logic gates, Optogenetic stimulation, Optogenetics, piezoelectric, rectifier, Rectifiers, Substrates, Ultrasonic power transfer",

author = "Kjeld Laursen and Milad Zamani and Yasser Rezaeiyan and Seyedsina Hosseini and Tanmay Mondal and Brian Corbett and Ouagazzal, {Abdel Mouttalib} and Marianne Amalric and Farshad Moradi",

note = "Green Open Access added to TU Delft Institutional Repository {\textquoteleft}You share, we take care!{\textquoteright} – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public. ",

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AU - Hosseini, Seyedsina

AU - Mondal, Tanmay

AU - Corbett, Brian

AU - Ouagazzal, Abdel Mouttalib

AU - Amalric, Marianne

AU - Moradi, Farshad

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N2 - This brief presents an ultrasonically powered micro-system for deep tissue optogenetic stimulation. The developed system is composed of a Base for Powering and Controlling (BPC) and an implantable Dust for optogenetics and drug delivery. The Dust consists of a piezoelectric crystal, a rectifier chip, and a micro-scale custom-designed light-emitting-diode (μ LED) integrated, miniaturized, and envisioned to be used for freely moving animal studies. The proposed Dust operates in frequencies up to 5 MHz, power levels in the 0-10 mW range, achieves start-up within 1.8~μ s at 2.9 MHz operating frequency at 14.4 mW/mm2 ultrasound power density, and 98.1% chip efficiency at 2 mW input power. With the BPC implemented and attached to ( 500~μ m )3 PZT4 crystals, set to 60 V at 2.8 MHz operating frequency at 3 mm distance in demineralized water, the dust delivered up to 6 mW to its load (μ LED for optogenetics), which translates to 0.11% total system efficiency.

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